Nucleotide modifications in messenger RNA and their role in development and disease

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

External organisations

  • Coventry University
  • University of Birmingham

Abstract

Modified nucleotides in messenger RNA (mRNA) have been discovered over 40 years ago, but until recently little was known about which transcripts contain them and what their function is. High-throughput sequencing approaches revealed a dynamic landscape of the "Epitranscriptome" for many mRNA modifications in various organisms from yeast to humans. Meanwhile, also many genes encoding mRNA modifying enzymes and auxiliary proteins have been identified yielding functional insights by reverse genetics into their role in development and disease.

Details

Original languageEnglish
Pages (from-to)1385-1393
JournalBiochemical Society Transactions
Volume44
Issue number5
Early online date19 Oct 2016
Publication statusPublished - 2016

Keywords

  • ADAR mRNA editing, mRNA methylation, m6A, m5C, hm5C, pseudouridylation