Novel Polystyrene Sulfonate-Silica Microspheres as a Carrier of a Water Soluble Inorganic Salt (KCl) for Its Sustained Release, via a Dual-Release Mechanism
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Herein we describe a novel type of organic–inorganic composite solid microsphere, comprised of polystyrene sulfonate and silica (PSS–SiO2), which has been synthesised from polystyrene sulfonic acid and tetraethyl orthosilicate. The microsphere can (i) encapsulate a low molar mass (<100 Da) inorganic salt (KCl), and (ii) provide sustained release (>48 hours) of the salt from the microspheres to an aqueous environment, which has hitherto not been possible. We propose a novel dual-release mechanism of the salt from the microspheres, which leads to the sustained release, and therefore has potential applicability for the controlled and prolonged release of other actives.
|Early online date||3 Jan 2017|
|Publication status||Published - Jan 2017|