TY - JOUR
T1 - Novel inositol containing phospholipids and phosphates
T2 - their synthesis and possible new roles in cellular signalling
AU - Hughes, Philip J.
AU - Michell, Robert H.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Details of the widely employed Ptdlns(4,5)P2 hydrolysis receptor-stimulated signalling pathway continue to be elucidated rapidly. However, it has recently become apparent that numerous other inositol lipids and phosphates are widespread and are likely to have important cellular functions. In this review, we focus particularly on three rapidly progressing areas: the synthesis and possible functions of 3-phosphorylated inositol lipids, particularly phosphatidylinositol 3,4,5-trisphosphate; the roles of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in coordinating intracellular Cat+ mobilization and Ca2+ influx in stimulated cells; and the metabolism and possible functions of other inositol polyphosphates and of inositol polyphosphate pyrophosphates.
AB - Details of the widely employed Ptdlns(4,5)P2 hydrolysis receptor-stimulated signalling pathway continue to be elucidated rapidly. However, it has recently become apparent that numerous other inositol lipids and phosphates are widespread and are likely to have important cellular functions. In this review, we focus particularly on three rapidly progressing areas: the synthesis and possible functions of 3-phosphorylated inositol lipids, particularly phosphatidylinositol 3,4,5-trisphosphate; the roles of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in coordinating intracellular Cat+ mobilization and Ca2+ influx in stimulated cells; and the metabolism and possible functions of other inositol polyphosphates and of inositol polyphosphate pyrophosphates.
UR - http://www.scopus.com/inward/record.url?scp=0027169747&partnerID=8YFLogxK
U2 - 10.1016/0959-4388(93)90132-I
DO - 10.1016/0959-4388(93)90132-I
M3 - Article
C2 - 8369629
AN - SCOPUS:0027169747
SN - 0959-4388
VL - 3
SP - 383
EP - 400
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 3
ER -