Novel C,N-chelate platinum(II) antitumor complexes bearing a lipophilic ethisterone pendant

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

The novel steroidal carrier ligand 17-alpha[4'-ethynyl-dimethylbenzylamine]-17-beta-testosterone (ET-dmba 1) and the steroid - C,N-chelate platinum(II) derivatives [Pt(ET-dmba)Cl(L)] (L = DMSO (2) and PTA (3; PTA = 1,3,5-triaza-7-phosphaadamantane)) have been prepared. Values of IC50 were calculated for the new platinum complexes 2 and 3 against a panel of human tumor cell lines representative of ovarian (A2780 and A2780cisR) and breast cancers (T47D). At 48 h incubation time complexes 2 and 3 show very low resistance factors (RF of

Details

Original languageEnglish
Pages (from-to)525-531
Number of pages7
JournalJournal of Inorganic Biochemistry
Volume105
Issue number4
Publication statusPublished - 1 Apr 2011

Keywords

  • Cytotoxicity, Lipophilicity, Steroidal derivative, DNA, Platinum complexes