TY - JOUR
T1 - Non-steroidal anti-inflammatory drugs; overall risks and management. Complementary roles for COX-2 inhibitors and proton pump inhibitors
AU - Hawkey, CJ
AU - Langman, Michael
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Non-steroidal anti-inflammatory drugs (NSAIDs) are well recognised as causing peptic ulceration and ulcer complications. However, several critical issues, including the amount of both gastrointestinal and non-gastrointestinal disease affected by NSAIDs, their interaction with ancillary risk factors, and how to optimise management in subgroups, remain poorly understood. In this article, strategies for subgroups that take account of non-specific gastrointestinal risks, minimisation of residual risk, and the importance of non-gastrointestinal toxicity are suggested, and areas for research identified.
AB - Non-steroidal anti-inflammatory drugs (NSAIDs) are well recognised as causing peptic ulceration and ulcer complications. However, several critical issues, including the amount of both gastrointestinal and non-gastrointestinal disease affected by NSAIDs, their interaction with ancillary risk factors, and how to optimise management in subgroups, remain poorly understood. In this article, strategies for subgroups that take account of non-specific gastrointestinal risks, minimisation of residual risk, and the importance of non-gastrointestinal toxicity are suggested, and areas for research identified.
UR - http://www.scopus.com/inward/record.url?scp=0037377905&partnerID=8YFLogxK
U2 - 10.1136/gut.52.4.600
DO - 10.1136/gut.52.4.600
M3 - Article
C2 - 12631678
SN - 1468-3288
VL - 52
SP - 600
EP - 608
JO - Gut
JF - Gut
IS - 4
ER -