Abstract
In 3 years seventeen patients presented to one unit with renal failure associated with the use of non-steroidal anti-inflammatory drugs (NSAID). Seven patients presented with acute renal failure, in four due to acute tubular necrosis and in three to acute interstitial nephritis; all recovered when NSAID treatment was stopped. Four patients presented with symptomless renal impairment discovered during routine follow-up in a rheumatology clinic; again all improved on withdrawal of NSAID. The remaining six patients presented with chronic renal failure, a disorder not previously associated with NSAID treatment. The pattern of renal disease associated with NSAID may be more extensive than has previously been recognised. A history of NSAID use should be sought in all patients presenting with unexplained renal failure.
Original language | English |
---|---|
Pages (from-to) | 57-60 |
Number of pages | 4 |
Journal | Lancet |
Volume | 1 |
Issue number | 8472 |
Publication status | Published - 11 Jan 1986 |
Keywords
- Acute Kidney Injury
- Adult
- Aged
- Anti-Inflammatory Agents
- Apazone
- Creatinine
- Female
- Humans
- Kidney Failure, Chronic
- Kidney Tubular Necrosis, Acute
- Male
- Middle Aged
- Naproxen
- Nephritis, Interstitial
- Piroxicam
- Proteinuria
- Thiazines