Non-steroidal anti-inflammatory drugs and renal failure

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In 3 years seventeen patients presented to one unit with renal failure associated with the use of non-steroidal anti-inflammatory drugs (NSAID). Seven patients presented with acute renal failure, in four due to acute tubular necrosis and in three to acute interstitial nephritis; all recovered when NSAID treatment was stopped. Four patients presented with symptomless renal impairment discovered during routine follow-up in a rheumatology clinic; again all improved on withdrawal of NSAID. The remaining six patients presented with chronic renal failure, a disorder not previously associated with NSAID treatment. The pattern of renal disease associated with NSAID may be more extensive than has previously been recognised. A history of NSAID use should be sought in all patients presenting with unexplained renal failure.


Original languageEnglish
Pages (from-to)57-60
Number of pages4
Issue number8472
Publication statusPublished - 11 Jan 1986


  • Acute Kidney Injury, Adult, Aged, Anti-Inflammatory Agents, Apazone, Creatinine, Female, Humans, Kidney Failure, Chronic, Kidney Tubular Necrosis, Acute, Male, Middle Aged, Naproxen, Nephritis, Interstitial, Piroxicam, Proteinuria, Thiazines