Abstract
Purpose: Anterior chamber (AC) flare is a key sign for anterior uveitis. New instrument-based techniques for measuring AC flare can offer automation and objectivity. This review aims to identify objective instrument-based measures of AC flare.
Methods: In this systematic review, we identified studies reporting correlation between instrument-based tests versus clinician AC flare grading, and/or aqueous protein concentration, as well as test reliability.
Results: Four index tests were identified in 11 studies: laser-flare photometry (LFP), optical coherence tomography, ocular flare analysis meter (OFAM) and the double-pass technique. The correlation between LFP and clinician grading and protein concentration was 0.40-0.93 and 0.87-0.94, respectively. The double-pass technique showed no correlation with clinician grading and insufficient information was available for OFAM.
Conclusion: LFP shows moderate to strong correlation with clinician grading and aqueous protein concentration. LFP could be a superior reference test compared to clinician AC flare grading for validating new index tests.
Methods: In this systematic review, we identified studies reporting correlation between instrument-based tests versus clinician AC flare grading, and/or aqueous protein concentration, as well as test reliability.
Results: Four index tests were identified in 11 studies: laser-flare photometry (LFP), optical coherence tomography, ocular flare analysis meter (OFAM) and the double-pass technique. The correlation between LFP and clinician grading and protein concentration was 0.40-0.93 and 0.87-0.94, respectively. The double-pass technique showed no correlation with clinician grading and insufficient information was available for OFAM.
Conclusion: LFP shows moderate to strong correlation with clinician grading and aqueous protein concentration. LFP could be a superior reference test compared to clinician AC flare grading for validating new index tests.
Original language | English |
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Journal | Ocular immunology and inflammation |
Publication status | Accepted/In press - 23 Dec 2019 |
Keywords
- Systematic review
- uveitis
- anterior chamber flare
- aqueous humor
- aqueous humour
- Tyndall effect
- diagnostic test
- aqueous protein concentration
- optical coherence tomography
- laser flare photometry