Non-invasive cerebellar stimulation-: -a consensus paper

Research output: Contribution to journalArticlepeer-review

Standard

Non-invasive cerebellar stimulation- : -a consensus paper. / Grimaldi, G; Argyropoulos, GP; Boehringer, A; Celnik, Pablo; Edwards, Mark; Ferrucci, R; Galea, Joseph; Groiss, SJ; Hiraoka, K; Kassavetis, P; Lesage, Elise; Manto, M; Miall, Rowland; Priori, A; Sadnicka, A; Ugawa, Y; Ziemann, U.

In: The Cerebellum, Vol. 13, No. 1, 02.2014, p. 121-138.

Research output: Contribution to journalArticlepeer-review

Harvard

Grimaldi, G, Argyropoulos, GP, Boehringer, A, Celnik, P, Edwards, M, Ferrucci, R, Galea, J, Groiss, SJ, Hiraoka, K, Kassavetis, P, Lesage, E, Manto, M, Miall, R, Priori, A, Sadnicka, A, Ugawa, Y & Ziemann, U 2014, 'Non-invasive cerebellar stimulation-: -a consensus paper', The Cerebellum, vol. 13, no. 1, pp. 121-138. https://doi.org/10.1007/s12311-013-0514-7

APA

Grimaldi, G., Argyropoulos, GP., Boehringer, A., Celnik, P., Edwards, M., Ferrucci, R., Galea, J., Groiss, SJ., Hiraoka, K., Kassavetis, P., Lesage, E., Manto, M., Miall, R., Priori, A., Sadnicka, A., Ugawa, Y., & Ziemann, U. (2014). Non-invasive cerebellar stimulation-: -a consensus paper. The Cerebellum, 13(1), 121-138. https://doi.org/10.1007/s12311-013-0514-7

Vancouver

Grimaldi G, Argyropoulos GP, Boehringer A, Celnik P, Edwards M, Ferrucci R et al. Non-invasive cerebellar stimulation-: -a consensus paper. The Cerebellum. 2014 Feb;13(1):121-138. https://doi.org/10.1007/s12311-013-0514-7

Author

Grimaldi, G ; Argyropoulos, GP ; Boehringer, A ; Celnik, Pablo ; Edwards, Mark ; Ferrucci, R ; Galea, Joseph ; Groiss, SJ ; Hiraoka, K ; Kassavetis, P ; Lesage, Elise ; Manto, M ; Miall, Rowland ; Priori, A ; Sadnicka, A ; Ugawa, Y ; Ziemann, U. / Non-invasive cerebellar stimulation- : -a consensus paper. In: The Cerebellum. 2014 ; Vol. 13, No. 1. pp. 121-138.

Bibtex

@article{1e9aaf7a42a64879a0cf31742a773386,
title = "Non-invasive cerebellar stimulation-: -a consensus paper",
abstract = "The field of neurostimulation of the cerebellum either with transcranial magnetic stimulation (TMS; single pulse or repetitive (rTMS)) or transcranial direct current stim- ulation (tDCS; anodal or cathodal) is gaining popularity in the scientific community, in particular because these stimulation techniques are non-invasive and provide novel information on cerebellar functions. There is a consensus amongst the panel of experts that both TMS and tDCS can effectively influence cerebellar functions, not only in the motor domain, with effects on visually guided tracking tasks, motor surround inhibition, motor adaptation and learning, but also for the cognitive and affective operations handled by the cerebro- cerebellar circuits. Verbal working memory, semantic associ- ations and predictive language processing are amongst these operations. Both TMS and tDCS modulate the connectivity between the cerebellum and the primary motor cortex, tuning cerebellar excitability. Cerebellar TMS is an effective and valuable method to evaluate the cerebello-thalamo-cortical loop functions and for the study of the pathophysiology of ataxia. In most circumstances, DCS induces a polarity- dependent site-specific modulation of cerebellar activity. Paired associative stimulation of the cerebello-dentato- thalamo-M1 pathway can induce bidirectional long-term spike-timing-dependent plasticity-like changes of corticospinal excitability. However, the panel of experts considers that sev- eral important issues still remain unresolved and require further research. In particular, the role of TMS in promoting cerebellar plasticity is not established. Moreover, the exact positioning of electrode stimulation and the duration of the after effects of tDCS remain unclear. Future studies are required to better define how DCS over particular regions of the cerebellum affects individual cerebellar symptoms, given the topographi- cal organization of cerebellar symptoms. The long-term neural consequences of non-invasive cerebellar modulation are also unclear. Although there is an agreement that the clinical appli- cations in cerebellar disorders are likely numerous, it is em- phasized that rigorous large-scale clinical trials are missing. Further studies should be encouraged to better clarify the role of using non-invasive neurostimulation techniques over the cerebellum in motor, cognitive and psychiatric rehabilitation strategies.",
keywords = "Cerebellum , Transcranial Magnetic Stimulation, Direct current stimulation , Anodal, Cathodal, Motor adaptation, Excitability, Cerebellar inhibition, Paired associative stimulation, Vision, Language, Predictions , Motor surround inhibition, Working memory, Semantic associations, Ataxia",
author = "G Grimaldi and GP Argyropoulos and A Boehringer and Pablo Celnik and Mark Edwards and R Ferrucci and Joseph Galea and SJ Groiss and K Hiraoka and P Kassavetis and Elise Lesage and M Manto and Rowland Miall and A Priori and A Sadnicka and Y Ugawa and U Ziemann",
year = "2014",
month = feb,
doi = "10.1007/s12311-013-0514-7",
language = "English",
volume = "13",
pages = "121--138",
journal = "The Cerebellum",
issn = "1473-4222",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Non-invasive cerebellar stimulation-

T2 - -a consensus paper

AU - Grimaldi, G

AU - Argyropoulos, GP

AU - Boehringer, A

AU - Celnik, Pablo

AU - Edwards, Mark

AU - Ferrucci, R

AU - Galea, Joseph

AU - Groiss, SJ

AU - Hiraoka, K

AU - Kassavetis, P

AU - Lesage, Elise

AU - Manto, M

AU - Miall, Rowland

AU - Priori, A

AU - Sadnicka, A

AU - Ugawa, Y

AU - Ziemann, U

PY - 2014/2

Y1 - 2014/2

N2 - The field of neurostimulation of the cerebellum either with transcranial magnetic stimulation (TMS; single pulse or repetitive (rTMS)) or transcranial direct current stim- ulation (tDCS; anodal or cathodal) is gaining popularity in the scientific community, in particular because these stimulation techniques are non-invasive and provide novel information on cerebellar functions. There is a consensus amongst the panel of experts that both TMS and tDCS can effectively influence cerebellar functions, not only in the motor domain, with effects on visually guided tracking tasks, motor surround inhibition, motor adaptation and learning, but also for the cognitive and affective operations handled by the cerebro- cerebellar circuits. Verbal working memory, semantic associ- ations and predictive language processing are amongst these operations. Both TMS and tDCS modulate the connectivity between the cerebellum and the primary motor cortex, tuning cerebellar excitability. Cerebellar TMS is an effective and valuable method to evaluate the cerebello-thalamo-cortical loop functions and for the study of the pathophysiology of ataxia. In most circumstances, DCS induces a polarity- dependent site-specific modulation of cerebellar activity. Paired associative stimulation of the cerebello-dentato- thalamo-M1 pathway can induce bidirectional long-term spike-timing-dependent plasticity-like changes of corticospinal excitability. However, the panel of experts considers that sev- eral important issues still remain unresolved and require further research. In particular, the role of TMS in promoting cerebellar plasticity is not established. Moreover, the exact positioning of electrode stimulation and the duration of the after effects of tDCS remain unclear. Future studies are required to better define how DCS over particular regions of the cerebellum affects individual cerebellar symptoms, given the topographi- cal organization of cerebellar symptoms. The long-term neural consequences of non-invasive cerebellar modulation are also unclear. Although there is an agreement that the clinical appli- cations in cerebellar disorders are likely numerous, it is em- phasized that rigorous large-scale clinical trials are missing. Further studies should be encouraged to better clarify the role of using non-invasive neurostimulation techniques over the cerebellum in motor, cognitive and psychiatric rehabilitation strategies.

AB - The field of neurostimulation of the cerebellum either with transcranial magnetic stimulation (TMS; single pulse or repetitive (rTMS)) or transcranial direct current stim- ulation (tDCS; anodal or cathodal) is gaining popularity in the scientific community, in particular because these stimulation techniques are non-invasive and provide novel information on cerebellar functions. There is a consensus amongst the panel of experts that both TMS and tDCS can effectively influence cerebellar functions, not only in the motor domain, with effects on visually guided tracking tasks, motor surround inhibition, motor adaptation and learning, but also for the cognitive and affective operations handled by the cerebro- cerebellar circuits. Verbal working memory, semantic associ- ations and predictive language processing are amongst these operations. Both TMS and tDCS modulate the connectivity between the cerebellum and the primary motor cortex, tuning cerebellar excitability. Cerebellar TMS is an effective and valuable method to evaluate the cerebello-thalamo-cortical loop functions and for the study of the pathophysiology of ataxia. In most circumstances, DCS induces a polarity- dependent site-specific modulation of cerebellar activity. Paired associative stimulation of the cerebello-dentato- thalamo-M1 pathway can induce bidirectional long-term spike-timing-dependent plasticity-like changes of corticospinal excitability. However, the panel of experts considers that sev- eral important issues still remain unresolved and require further research. In particular, the role of TMS in promoting cerebellar plasticity is not established. Moreover, the exact positioning of electrode stimulation and the duration of the after effects of tDCS remain unclear. Future studies are required to better define how DCS over particular regions of the cerebellum affects individual cerebellar symptoms, given the topographi- cal organization of cerebellar symptoms. The long-term neural consequences of non-invasive cerebellar modulation are also unclear. Although there is an agreement that the clinical appli- cations in cerebellar disorders are likely numerous, it is em- phasized that rigorous large-scale clinical trials are missing. Further studies should be encouraged to better clarify the role of using non-invasive neurostimulation techniques over the cerebellum in motor, cognitive and psychiatric rehabilitation strategies.

KW - Cerebellum

KW - Transcranial Magnetic Stimulation

KW - Direct current stimulation

KW - Anodal

KW - Cathodal

KW - Motor adaptation

KW - Excitability

KW - Cerebellar inhibition

KW - Paired associative stimulation

KW - Vision

KW - Language

KW - Predictions

KW - Motor surround inhibition

KW - Working memory

KW - Semantic associations

KW - Ataxia

U2 - 10.1007/s12311-013-0514-7

DO - 10.1007/s12311-013-0514-7

M3 - Article

VL - 13

SP - 121

EP - 138

JO - The Cerebellum

JF - The Cerebellum

SN - 1473-4222

IS - 1

ER -