TY - JOUR
T1 - Non-genomic effects of endocrine disrupters: inhibition of estrogen sulfotransferase by phenols and chlorinated phenols
AU - Harris, Robert
AU - Kirk, Christopher
AU - Waring, Rosemary
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Phenols are used world-wide and their presence in the environment is a cause of increasing concern. Despite evidence to suggest that, in general, they bind poorly to estrogen receptors, they are suspected of being endocrine disrupters. Here, we show that 2, x-substituted phenols are potent inhibitors of estrogen sulfotransferase with IC(50) values at low- or sub-micromolar levels. Our results demonstrate a potential non-genomic mechanism of action for these compounds and suggest that, where viable alternatives exist, both phenols substituted in the 2-position and their metabolic precursors should be avoided.
AB - Phenols are used world-wide and their presence in the environment is a cause of increasing concern. Despite evidence to suggest that, in general, they bind poorly to estrogen receptors, they are suspected of being endocrine disrupters. Here, we show that 2, x-substituted phenols are potent inhibitors of estrogen sulfotransferase with IC(50) values at low- or sub-micromolar levels. Our results demonstrate a potential non-genomic mechanism of action for these compounds and suggest that, where viable alternatives exist, both phenols substituted in the 2-position and their metabolic precursors should be avoided.
KW - environmental chemical
KW - structure-activity relationship
KW - endocrine disrupter
KW - inhibitor
KW - chlorinated phenol
KW - SULT 1E1
UR - http://www.scopus.com/inward/record.url?scp=27744599111&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2005.05.013
DO - 10.1016/j.mce.2005.05.013
M3 - Article
C2 - 16266779
VL - 244
SP - 72
EP - 74
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
IS - 1-2
ER -