Non-genomic effects of endocrine disrupters: inhibition of estrogen sulfotransferase by phenols and chlorinated phenols

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

Phenols are used world-wide and their presence in the environment is a cause of increasing concern. Despite evidence to suggest that, in general, they bind poorly to estrogen receptors, they are suspected of being endocrine disrupters. Here, we show that 2, x-substituted phenols are potent inhibitors of estrogen sulfotransferase with IC(50) values at low- or sub-micromolar levels. Our results demonstrate a potential non-genomic mechanism of action for these compounds and suggest that, where viable alternatives exist, both phenols substituted in the 2-position and their metabolic precursors should be avoided.

Details

Original languageEnglish
Pages (from-to)72-74
Number of pages3
JournalMolecular and Cellular Endocrinology
Volume244
Issue number1-2
Publication statusPublished - 1 Dec 2005

Keywords

  • environmental chemical, structure-activity relationship, endocrine disrupter, inhibitor, chlorinated phenol, SULT 1E1