Non-covalent metallo-drugs: using shape to target DNA and RNA junctions and other nucleic acid structures
Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)
Authors
Colleges, School and Institutes
Abstract
The most effective class of anticancer drugs in clinical use are the platins which act by binding to duplex B-DNA. Yet duplex DNA is not DNA in its active form, and many other structures are formed in cells; for example, Y-shaped fork structures are involved in DNA replication and transcription and 4-way junctions with DNA repair. In this chapter we explore how large, cationic metallo-supramolecular structures can be used to bind to these less common, yet active, nucleic acid structures.
Details
| Original language | English |
|---|---|
| Title of host publication | Metallo-drugs |
| Subtitle of host publication | Development and Action of Anticancer Agents |
| Publication status | Published - 5 Feb 2018 |
Publication series
| Name | Metal Ions in Life Sciences |
|---|---|
| Volume | 18 |
| ISSN (Print) | 1559-0836 |
| ISSN (Electronic) | 1868-0402 |
Keywords
- Animals, Antineoplastic Agents/chemistry, Binding Sites, Coordination Complexes, DNA, Neoplasm/chemistry, Drug Design, G-Quadruplexes, Humans, Models, Molecular, Neoplasms/drug therapy, Nucleic Acid Conformation, Organometallic Compounds/chemistry, RNA, Neoplasm/chemistry, Structure-Activity Relationship