Non-covalent metallo-drugs: using shape to target DNA and RNA junctions and other nucleic acid structures

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Colleges, School and Institutes

Abstract

The most effective class of anticancer drugs in clinical use are the platins which act by binding to duplex B-DNA. Yet duplex DNA is not DNA in its active form, and many other structures are formed in cells; for example, Y-shaped fork structures are involved in DNA replication and transcription and 4-way junctions with DNA repair. In this chapter we explore how large, cationic metallo-supramolecular structures can be used to bind to these less common, yet active, nucleic acid structures.

Details

Original languageEnglish
Title of host publicationMetallo-drugs
Subtitle of host publicationDevelopment and Action of Anticancer Agents
Publication statusPublished - 5 Feb 2018

Publication series

NameMetal Ions in Life Sciences
Volume18
ISSN (Print)1559-0836
ISSN (Electronic)1868-0402

Keywords

  • Animals, Antineoplastic Agents/chemistry, Binding Sites, Coordination Complexes, DNA, Neoplasm/chemistry, Drug Design, G-Quadruplexes, Humans, Models, Molecular, Neoplasms/drug therapy, Nucleic Acid Conformation, Organometallic Compounds/chemistry, RNA, Neoplasm/chemistry, Structure-Activity Relationship