Non-covalent metallo-drugs: using shape to target DNA and RNA junctions and other nucleic acid structures
Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
The most effective class of anticancer drugs in clinical use are the platins which act by binding to duplex B-DNA. Yet duplex DNA is not DNA in its active form, and many other structures are formed in cells; for example, Y-shaped fork structures are involved in DNA replication and transcription and 4-way junctions with DNA repair. In this chapter we explore how large, cationic metallo-supramolecular structures can be used to bind to these less common, yet active, nucleic acid structures.
|Title of host publication||Metallo-drugs|
|Subtitle of host publication||Development and Action of Anticancer Agents|
|Publication status||Published - 5 Feb 2018|
|Name||Metal Ions in Life Sciences|
- Animals, Antineoplastic Agents/chemistry, Binding Sites, Coordination Complexes, DNA, Neoplasm/chemistry, Drug Design, G-Quadruplexes, Humans, Models, Molecular, Neoplasms/drug therapy, Nucleic Acid Conformation, Organometallic Compounds/chemistry, RNA, Neoplasm/chemistry, Structure-Activity Relationship