Nomenclature of the finer branches of the biliary tree: canals, ductules and ductural reactions in human livers

Research output: Contribution to journalArticle


  • N Theise
  • T Roskams
  • C Balabaud
  • G Bhagat
  • PS Bhatal

Colleges, School and Institutes


The work of liver stem cell biologists, largely carried out in rodent models, has now started to manifest in human investigations and applications. We can now recognize complex regenerative processes in tissue specimens that had only been suspected for decades, but we also struggle to describe what we see in human tissues in a way that takes into account the findings from the animal investigations, using a language derived from species not, in fact, so much like our own. This international group of liver pathologists and hepatologists, most of whom are actively engaged in both clinical work and scientific research, seeks to arrive at a consensus on nomenclature for normal human livers and human reactive lesions that can facilitate more rapid advancement of our field.


Original languageEnglish
Pages (from-to)1739-1745
Number of pages7
Early online date1 Jan 2004
Publication statusPublished - 1 Jan 2004


  • hepatic and hematpoietic stem cells, liver differentiation, oval cell