Noisy neighbourhoods : quorum sensing in fungal–polymicrobial infections

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Noisy neighbourhoods : quorum sensing in fungal–polymicrobial infections. / Dixon, Emily; Hall, Rebecca.

In: Cellular Microbiology, Vol. 17, No. 10, 24.09.2015, p. 1431–1441.

Research output: Contribution to journalReview articlepeer-review

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@article{1490b1353bc6426fb1350c39015210b5,
title = "Noisy neighbourhoods : quorum sensing in fungal–polymicrobial infections",
abstract = "Quorum sensing was once considered a way in which a species was able to sense its cell density and regulate gene expression accordingly. However, it is now becoming apparent that multiple microbes can sense particular quorum sensing molecules, enabling them to sense and respond to other microbes in their neighbourhood. Such interactions are significant within the context of polymicrobial disease, in which the competition or cooperation of microbes can alter disease progression. Fungi comprise a small but important component of the human microbiome and are in constant contact with bacteria and viruses. The discovery of quorum sensing pathways in fungi has led to the characterisation of a number of interkingdom quorum sensing interactions. Here, we review the recent developments in quorum sensing in medically important fungi, and the implications these interactions have on the host{\textquoteright}s innate immune response. ",
author = "Emily Dixon and Rebecca Hall",
year = "2015",
month = sep,
day = "24",
doi = "10.1111/cmi.12490",
language = "English",
volume = "17",
pages = "1431–1441",
journal = "Cellular Microbiology",
issn = "1462-5814",
publisher = "Wiley",
number = "10",

}

RIS

TY - JOUR

T1 - Noisy neighbourhoods : quorum sensing in fungal–polymicrobial infections

AU - Dixon, Emily

AU - Hall, Rebecca

PY - 2015/9/24

Y1 - 2015/9/24

N2 - Quorum sensing was once considered a way in which a species was able to sense its cell density and regulate gene expression accordingly. However, it is now becoming apparent that multiple microbes can sense particular quorum sensing molecules, enabling them to sense and respond to other microbes in their neighbourhood. Such interactions are significant within the context of polymicrobial disease, in which the competition or cooperation of microbes can alter disease progression. Fungi comprise a small but important component of the human microbiome and are in constant contact with bacteria and viruses. The discovery of quorum sensing pathways in fungi has led to the characterisation of a number of interkingdom quorum sensing interactions. Here, we review the recent developments in quorum sensing in medically important fungi, and the implications these interactions have on the host’s innate immune response.

AB - Quorum sensing was once considered a way in which a species was able to sense its cell density and regulate gene expression accordingly. However, it is now becoming apparent that multiple microbes can sense particular quorum sensing molecules, enabling them to sense and respond to other microbes in their neighbourhood. Such interactions are significant within the context of polymicrobial disease, in which the competition or cooperation of microbes can alter disease progression. Fungi comprise a small but important component of the human microbiome and are in constant contact with bacteria and viruses. The discovery of quorum sensing pathways in fungi has led to the characterisation of a number of interkingdom quorum sensing interactions. Here, we review the recent developments in quorum sensing in medically important fungi, and the implications these interactions have on the host’s innate immune response.

U2 - 10.1111/cmi.12490

DO - 10.1111/cmi.12490

M3 - Review article

C2 - 26243526

VL - 17

SP - 1431

EP - 1441

JO - Cellular Microbiology

JF - Cellular Microbiology

SN - 1462-5814

IS - 10

ER -