No evidence for allelic association of a human CTLA-4 promoter polymorphism with autoimmune thyroid disease in either population-based case-control or family-based studies
Research output: Contribution to journal › Article › peer-review
The cytotoxic T lymphocyte associated-4 (CTLA-4) gene is a candidate for T-cell mediated autoimmune disease and polymorphism has been reported to be associated with both type 1 diabetes and autoimmune thyroid disease. A previously unreported polymorphism of the promoter region of the human CTLA-4 gene has recently been described in a sample of a normal control population. We investigated the distribution of this polymorphism, situated at position -318 to the ATG start codon and resulting in a C-T change leading to an Mse I restriction site, in both population based case control studies and family studies in patients with Graves' disease (Caucasian and Hong Kong Chinese), autoimmune hypothyroidism and systemic lupus erythematosus (SLE).
|Number of pages||4|
|Publication status||Published - Sep 1998|
- Alleles, Antigens, CD, Antigens, Differentiation, Autoimmune Diseases, CTLA-4 Antigen, Case-Control Studies, China, Genotype, Graves Disease, Hong Kong, Humans, Hypothyroidism, Immunoconjugates, Lupus Erythematosus, Systemic, Polymorphism, Genetic, Promoter Regions, Genetic, Thyroid Diseases