No effect of acute L-arginine supplementation on O(2) cost or exercise tolerance

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No effect of acute L-arginine supplementation on O(2) cost or exercise tolerance. / Vanhatalo, Anni; Bailey, Stephen J; Dimenna, Fred J; Blackwell, Jamie R; Wallis, Gareth; Jones, Andrew M.

In: European journal of applied physiology, 20.02.2013.

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Vanhatalo, Anni ; Bailey, Stephen J ; Dimenna, Fred J ; Blackwell, Jamie R ; Wallis, Gareth ; Jones, Andrew M. / No effect of acute L-arginine supplementation on O(2) cost or exercise tolerance. In: European journal of applied physiology. 2013.

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@article{3f01695f9ccc475c88464cca05d9d577,
title = "No effect of acute L-arginine supplementation on O(2) cost or exercise tolerance",
abstract = "The extent to which dietary supplementation with the nitric oxide synthase (NOS) substrate, L-arginine (ARG), impacts on NO production and NO-mediated physiological responses is controversial. This randomised, double blinded, cross-over study investigated the effects of acute ARG supplementation on NO biomarkers, O(2) cost of exercise and exercise tolerance in humans. In one experiment, 15 subjects completed moderate- and severe-intensity running bouts after acute supplementation with 6 g ARG or placebo (PLA). In another experiment, eight subjects completed moderate- and severe-intensity cycling bouts after acute supplementation with 6 g ARG plus 25 g of carbohydrate (ARG + CHO) or an energy-matched dose of carbohydrate alone (CHO). The plasma nitrite concentration was not different after ARG (Pre: 204 ± 79; Post: 241 ± 114 nM; P > 0.05) or ARG + CHO consumption (Pre: 304 ± 57; Post: 335 ± 116 nM; P > 0.05). During moderate-intensity exercise, the steady-state pulmonary [Formula: see text] was not different, relative to the respective placebo conditions, after ARG (PLA: 2,407 ± 318, ARG: 2,422 ± 333 mL min(-1)) or ARG + CHO (CHO: 1,695 ± 304, ARG + CHO: 1,712 ± 312 mL min(-1)) ingestion (P > 0.05). The tolerable duration of severe exercise was also not significantly different (P > 0.05) after ingesting ARG (PLA: 551 ± 140, ARG: 552 ± 150 s) or ARG + CHO (CHO: 457 ± 182, ARG + CHO: 441 ± 221 s). In conclusion, acute dietary supplementation with ARG or ARG + CHO did not alter biomarkers of NO synthesis, O(2) cost of exercise or exercise tolerance in healthy subjects.",
author = "Anni Vanhatalo and Bailey, {Stephen J} and Dimenna, {Fred J} and Blackwell, {Jamie R} and Gareth Wallis and Jones, {Andrew M}",
year = "2013",
month = feb,
day = "20",
doi = "10.1007/s00421-013-2593-z",
language = "English",
journal = "European journal of applied physiology",
issn = "1439-6319",
publisher = "Springer Verlag",

}

RIS

TY - JOUR

T1 - No effect of acute L-arginine supplementation on O(2) cost or exercise tolerance

AU - Vanhatalo, Anni

AU - Bailey, Stephen J

AU - Dimenna, Fred J

AU - Blackwell, Jamie R

AU - Wallis, Gareth

AU - Jones, Andrew M

PY - 2013/2/20

Y1 - 2013/2/20

N2 - The extent to which dietary supplementation with the nitric oxide synthase (NOS) substrate, L-arginine (ARG), impacts on NO production and NO-mediated physiological responses is controversial. This randomised, double blinded, cross-over study investigated the effects of acute ARG supplementation on NO biomarkers, O(2) cost of exercise and exercise tolerance in humans. In one experiment, 15 subjects completed moderate- and severe-intensity running bouts after acute supplementation with 6 g ARG or placebo (PLA). In another experiment, eight subjects completed moderate- and severe-intensity cycling bouts after acute supplementation with 6 g ARG plus 25 g of carbohydrate (ARG + CHO) or an energy-matched dose of carbohydrate alone (CHO). The plasma nitrite concentration was not different after ARG (Pre: 204 ± 79; Post: 241 ± 114 nM; P > 0.05) or ARG + CHO consumption (Pre: 304 ± 57; Post: 335 ± 116 nM; P > 0.05). During moderate-intensity exercise, the steady-state pulmonary [Formula: see text] was not different, relative to the respective placebo conditions, after ARG (PLA: 2,407 ± 318, ARG: 2,422 ± 333 mL min(-1)) or ARG + CHO (CHO: 1,695 ± 304, ARG + CHO: 1,712 ± 312 mL min(-1)) ingestion (P > 0.05). The tolerable duration of severe exercise was also not significantly different (P > 0.05) after ingesting ARG (PLA: 551 ± 140, ARG: 552 ± 150 s) or ARG + CHO (CHO: 457 ± 182, ARG + CHO: 441 ± 221 s). In conclusion, acute dietary supplementation with ARG or ARG + CHO did not alter biomarkers of NO synthesis, O(2) cost of exercise or exercise tolerance in healthy subjects.

AB - The extent to which dietary supplementation with the nitric oxide synthase (NOS) substrate, L-arginine (ARG), impacts on NO production and NO-mediated physiological responses is controversial. This randomised, double blinded, cross-over study investigated the effects of acute ARG supplementation on NO biomarkers, O(2) cost of exercise and exercise tolerance in humans. In one experiment, 15 subjects completed moderate- and severe-intensity running bouts after acute supplementation with 6 g ARG or placebo (PLA). In another experiment, eight subjects completed moderate- and severe-intensity cycling bouts after acute supplementation with 6 g ARG plus 25 g of carbohydrate (ARG + CHO) or an energy-matched dose of carbohydrate alone (CHO). The plasma nitrite concentration was not different after ARG (Pre: 204 ± 79; Post: 241 ± 114 nM; P > 0.05) or ARG + CHO consumption (Pre: 304 ± 57; Post: 335 ± 116 nM; P > 0.05). During moderate-intensity exercise, the steady-state pulmonary [Formula: see text] was not different, relative to the respective placebo conditions, after ARG (PLA: 2,407 ± 318, ARG: 2,422 ± 333 mL min(-1)) or ARG + CHO (CHO: 1,695 ± 304, ARG + CHO: 1,712 ± 312 mL min(-1)) ingestion (P > 0.05). The tolerable duration of severe exercise was also not significantly different (P > 0.05) after ingesting ARG (PLA: 551 ± 140, ARG: 552 ± 150 s) or ARG + CHO (CHO: 457 ± 182, ARG + CHO: 441 ± 221 s). In conclusion, acute dietary supplementation with ARG or ARG + CHO did not alter biomarkers of NO synthesis, O(2) cost of exercise or exercise tolerance in healthy subjects.

U2 - 10.1007/s00421-013-2593-z

DO - 10.1007/s00421-013-2593-z

M3 - Article

C2 - 23423302

JO - European journal of applied physiology

JF - European journal of applied physiology

SN - 1439-6319

ER -