TY - JOUR
T1 - No association between two polymorphisms at the 5HT2A gene and bipolar affective puerperal psychosis
AU - Robertson, Emma
AU - Jones, Ian
AU - Middle, Fiona
AU - Moray, J
AU - Craddock, Nicholas
PY - 2003/11/1
Y1 - 2003/11/1
N2 - Objective: To examine whether variation at two common polymorphisms, T102C and -1438AG, of the serotonin 2A gene (5HT2A) are involved in the puerperal triggering mechanism of bipolar affective puerperal psychosis. Method: A total of 242 parous women diagnosed with bipolar disorder were genotyped for the two polymorphisms. Of these, 165 women had experienced a manic or psychotic episode, according to DSM-IV criteria, within 6 weeks of childbirth ( the puerperal psychosis group). The comparison group comprised of 77 parous women who had not experienced psychiatric disturbance following childbirth. Results: No significant differences between genotype or allelic frequencies were found between the two groups for either polymorphism. Conclusion: The results indicate that variation at two common polymorphisms of the 5HT2A gene does not appear to play a major role in the development of bipolar affective puerperal psychosis.
AB - Objective: To examine whether variation at two common polymorphisms, T102C and -1438AG, of the serotonin 2A gene (5HT2A) are involved in the puerperal triggering mechanism of bipolar affective puerperal psychosis. Method: A total of 242 parous women diagnosed with bipolar disorder were genotyped for the two polymorphisms. Of these, 165 women had experienced a manic or psychotic episode, according to DSM-IV criteria, within 6 weeks of childbirth ( the puerperal psychosis group). The comparison group comprised of 77 parous women who had not experienced psychiatric disturbance following childbirth. Results: No significant differences between genotype or allelic frequencies were found between the two groups for either polymorphism. Conclusion: The results indicate that variation at two common polymorphisms of the 5HT2A gene does not appear to play a major role in the development of bipolar affective puerperal psychosis.
UR - http://www.scopus.com/inward/record.url?scp=0142215447&partnerID=8YFLogxK
U2 - 10.1034/j.1600-0447.2003.00167.x
DO - 10.1034/j.1600-0447.2003.00167.x
M3 - Article
C2 - 14531760
SN - 1600-0447
SN - 1600-0447
SN - 1600-0447
SN - 1600-0447
SN - 1600-0447
VL - 108
SP - 387
EP - 391
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
ER -