NK cells produce high levels of IL-10 early after allogeneic stem cell transplantation and suppress development of acute GVHD

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NK cells produce high levels of IL-10 early after allogeneic stem cell transplantation and suppress development of acute GVHD. / Chan, Yl Tracey; Zuo, Jianmin; Inman, Charlotte; Croft, Wayne; Begum, Jusnara; Croudace, Joanne; Kinsella, Francesca; Maggs, Luke; Nagra, Sandeep; Nunnick, Jane; Abbotts, Ben; Craddock, Charles; Malladi, Ram; Moss, Paul.

In: European Journal of Immunology, Vol. 48, No. 2, 22.02.2018, p. 316-329.

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@article{4c323b664049481ea027a10f12a68c0f,
title = "NK cells produce high levels of IL-10 early after allogeneic stem cell transplantation and suppress development of acute GVHD",
abstract = "Natural killer (NK) cells rapidly reconstitute following allogeneic stem cell transplantation (allo-SCT), at the time when alloreactive T cell immunity is being established. We investigated very early NK cell reconstitution in 82 patients following T cell-depleted allo-SCT. NK cell number rapidly increased, exceeding T cell reconstitution such that the NK:T cell ratio was over 40 by day 14. NK cells at day 14 (NK-14) were donor-derived, intensely proliferating and expressed chemokine receptors targeted to lymphoid and peripheral tissue. Spontaneous production of the immunoregulatory cytokine IL-10 was observed in over 70% of cells and transcription of cytokines and growth factors was augmented. NK-14 cell number was inversely correlated with the incidence of grade II-IV acute graft versus host disease (GVHD). These findings reveal that robust reconstitution of immunoregulatory NK cells by day 14 after allo-SCT is an important determinant of the clinical outcome, suggesting that NK cells may suppress the development of the T cell-mediated alloreactive immune response through production of IL-10. This article is protected by copyright. All rights reserved.",
keywords = "T cells depleted, Allo-SCT, GVHD , NK cells , IL-10 ",
author = "Chan, {Yl Tracey} and Jianmin Zuo and Charlotte Inman and Wayne Croft and Jusnara Begum and Joanne Croudace and Francesca Kinsella and Luke Maggs and Sandeep Nagra and Jane Nunnick and Ben Abbotts and Charles Craddock and Ram Malladi and Paul Moss",
note = "This article is protected by copyright. All rights reserved.",
year = "2018",
month = feb,
day = "22",
doi = "10.1002/eji.201747134",
language = "English",
volume = "48",
pages = "316--329",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag",
number = "2",

}

RIS

TY - JOUR

T1 - NK cells produce high levels of IL-10 early after allogeneic stem cell transplantation and suppress development of acute GVHD

AU - Chan, Yl Tracey

AU - Zuo, Jianmin

AU - Inman, Charlotte

AU - Croft, Wayne

AU - Begum, Jusnara

AU - Croudace, Joanne

AU - Kinsella, Francesca

AU - Maggs, Luke

AU - Nagra, Sandeep

AU - Nunnick, Jane

AU - Abbotts, Ben

AU - Craddock, Charles

AU - Malladi, Ram

AU - Moss, Paul

N1 - This article is protected by copyright. All rights reserved.

PY - 2018/2/22

Y1 - 2018/2/22

N2 - Natural killer (NK) cells rapidly reconstitute following allogeneic stem cell transplantation (allo-SCT), at the time when alloreactive T cell immunity is being established. We investigated very early NK cell reconstitution in 82 patients following T cell-depleted allo-SCT. NK cell number rapidly increased, exceeding T cell reconstitution such that the NK:T cell ratio was over 40 by day 14. NK cells at day 14 (NK-14) were donor-derived, intensely proliferating and expressed chemokine receptors targeted to lymphoid and peripheral tissue. Spontaneous production of the immunoregulatory cytokine IL-10 was observed in over 70% of cells and transcription of cytokines and growth factors was augmented. NK-14 cell number was inversely correlated with the incidence of grade II-IV acute graft versus host disease (GVHD). These findings reveal that robust reconstitution of immunoregulatory NK cells by day 14 after allo-SCT is an important determinant of the clinical outcome, suggesting that NK cells may suppress the development of the T cell-mediated alloreactive immune response through production of IL-10. This article is protected by copyright. All rights reserved.

AB - Natural killer (NK) cells rapidly reconstitute following allogeneic stem cell transplantation (allo-SCT), at the time when alloreactive T cell immunity is being established. We investigated very early NK cell reconstitution in 82 patients following T cell-depleted allo-SCT. NK cell number rapidly increased, exceeding T cell reconstitution such that the NK:T cell ratio was over 40 by day 14. NK cells at day 14 (NK-14) were donor-derived, intensely proliferating and expressed chemokine receptors targeted to lymphoid and peripheral tissue. Spontaneous production of the immunoregulatory cytokine IL-10 was observed in over 70% of cells and transcription of cytokines and growth factors was augmented. NK-14 cell number was inversely correlated with the incidence of grade II-IV acute graft versus host disease (GVHD). These findings reveal that robust reconstitution of immunoregulatory NK cells by day 14 after allo-SCT is an important determinant of the clinical outcome, suggesting that NK cells may suppress the development of the T cell-mediated alloreactive immune response through production of IL-10. This article is protected by copyright. All rights reserved.

KW - T cells depleted

KW - Allo-SCT

KW - GVHD

KW - NK cells

KW - IL-10

UR - http://europepmc.org/abstract/med/28944953

U2 - 10.1002/eji.201747134

DO - 10.1002/eji.201747134

M3 - Article

C2 - 28944953

VL - 48

SP - 316

EP - 329

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 2

ER -