Nicotinamide as independent variable for intelligence, fertility, and health: origin of human creative explosions?

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Nicotinamide as independent variable for intelligence, fertility, and health : origin of human creative explosions? / Williams, Adrian C; Hill, Lisa J.

In: International Journal of Tryptophan Research, Vol. 12, 19.06.2019, p. 1-15.

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@article{21ce529173734ac7bca5136f9fee328a,
title = "Nicotinamide as independent variable for intelligence, fertility, and health: origin of human creative explosions?",
abstract = "Meat and nicotinamide acquisition was a defining force during the 2-million-year evolution of the big brains necessary for, anatomically modern, Homo sapiens to survive. Our next move was down the food chain during the Mesolithic 'broad spectrum', then horticultural, followed by the Neolithic agricultural revolutions and progressively lower average 'doses' of nicotinamide. We speculate that a fertility crisis and population bottleneck around 40 000 years ago, at the time of the Last Glacial Maximum, was overcome by Homo (but not the Neanderthals) by concerted dietary change plus profertility genes and intense sexual selection culminating in behaviourally modern Homo sapiens. Increased reliance on the 'de novo' synthesis of nicotinamide from tryptophan conditioned the immune system to welcome symbionts, such as TB (that excrete nicotinamide), and to increase tolerance of the foetus and thereby fertility. The trade-offs during the warmer Holocene were physical and mental stunting and more infectious diseases and population booms and busts. Higher nicotinamide exposure could be responsible for recent demographic and epidemiological transitions to lower fertility and higher longevity, but with more degenerative and auto-immune disease.",
keywords = "neolithic, neanderthal, disease transitions, demographic transitions, immune tolerance, ‘K-selection’, ‘r-selection’, fertility, domestication",
author = "Williams, {Adrian C} and Hill, {Lisa J}",
year = "2019",
month = "6",
day = "19",
doi = "10.1177/1178646919855944",
language = "English",
volume = "12",
pages = "1--15",
journal = "International Journal of Tryptophan Research",
issn = "1178-6469",
publisher = "Libertas Academica Ltd.",

}

RIS

TY - JOUR

T1 - Nicotinamide as independent variable for intelligence, fertility, and health

T2 - origin of human creative explosions?

AU - Williams, Adrian C

AU - Hill, Lisa J

PY - 2019/6/19

Y1 - 2019/6/19

N2 - Meat and nicotinamide acquisition was a defining force during the 2-million-year evolution of the big brains necessary for, anatomically modern, Homo sapiens to survive. Our next move was down the food chain during the Mesolithic 'broad spectrum', then horticultural, followed by the Neolithic agricultural revolutions and progressively lower average 'doses' of nicotinamide. We speculate that a fertility crisis and population bottleneck around 40 000 years ago, at the time of the Last Glacial Maximum, was overcome by Homo (but not the Neanderthals) by concerted dietary change plus profertility genes and intense sexual selection culminating in behaviourally modern Homo sapiens. Increased reliance on the 'de novo' synthesis of nicotinamide from tryptophan conditioned the immune system to welcome symbionts, such as TB (that excrete nicotinamide), and to increase tolerance of the foetus and thereby fertility. The trade-offs during the warmer Holocene were physical and mental stunting and more infectious diseases and population booms and busts. Higher nicotinamide exposure could be responsible for recent demographic and epidemiological transitions to lower fertility and higher longevity, but with more degenerative and auto-immune disease.

AB - Meat and nicotinamide acquisition was a defining force during the 2-million-year evolution of the big brains necessary for, anatomically modern, Homo sapiens to survive. Our next move was down the food chain during the Mesolithic 'broad spectrum', then horticultural, followed by the Neolithic agricultural revolutions and progressively lower average 'doses' of nicotinamide. We speculate that a fertility crisis and population bottleneck around 40 000 years ago, at the time of the Last Glacial Maximum, was overcome by Homo (but not the Neanderthals) by concerted dietary change plus profertility genes and intense sexual selection culminating in behaviourally modern Homo sapiens. Increased reliance on the 'de novo' synthesis of nicotinamide from tryptophan conditioned the immune system to welcome symbionts, such as TB (that excrete nicotinamide), and to increase tolerance of the foetus and thereby fertility. The trade-offs during the warmer Holocene were physical and mental stunting and more infectious diseases and population booms and busts. Higher nicotinamide exposure could be responsible for recent demographic and epidemiological transitions to lower fertility and higher longevity, but with more degenerative and auto-immune disease.

KW - neolithic

KW - neanderthal

KW - disease transitions

KW - demographic transitions

KW - immune tolerance

KW - ‘K-selection’

KW - ‘r-selection’

KW - fertility

KW - domestication

U2 - 10.1177/1178646919855944

DO - 10.1177/1178646919855944

M3 - Review article

VL - 12

SP - 1

EP - 15

JO - International Journal of Tryptophan Research

JF - International Journal of Tryptophan Research

SN - 1178-6469

ER -