Next generation sequencing discoveries of the nitrate-responsive oral microbiome and its effect on vascular responses

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Next generation sequencing discoveries of the nitrate-responsive oral microbiome and its effect on vascular responses. / Grant, Melissa; Jonsson, Daniel.

In: Journal of Clinical Medicine, Vol. 8, No. 8, 1110, 26.07.2019.

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@article{74d282fccda24c5aa04d2f9ad0310ef3,
title = "Next generation sequencing discoveries of the nitrate-responsive oral microbiome and its effect on vascular responses",
abstract = "Cardiovascular disease is a worldwide human condition which has multiple underlying contributing factors: one of these is long-term increased blood pressure—hypertension. Nitric oxide (NO) is a small nitrogenous radical species that has a number of physiological functions including vasodilation. It can be produced enzymatically through host nitric oxide synthases and by an alternative nitrate–nitrite–NO pathway from ingested inorganic nitrate. It was discovered that this route relies on the ability of the oral microbiota to reduce nitrate to nitrite and NO. Next generation sequencing has been used over the past two decades to gain deeper insight into the microbes involved, their location and the effect of their removal from the oral cavity. This review article presents this research and comments briefly on future directions.",
keywords = "oral microbiome, saliva, nitric oxide, nitrate, nitrite",
author = "Melissa Grant and Daniel Jonsson",
year = "2019",
month = jul,
day = "26",
doi = "10.3390/jcm8081110",
language = "English",
volume = "8",
journal = "Journal of Clinical Medicine",
issn = "2077-0383",
publisher = "MDPI",
number = "8",

}

RIS

TY - JOUR

T1 - Next generation sequencing discoveries of the nitrate-responsive oral microbiome and its effect on vascular responses

AU - Grant, Melissa

AU - Jonsson, Daniel

PY - 2019/7/26

Y1 - 2019/7/26

N2 - Cardiovascular disease is a worldwide human condition which has multiple underlying contributing factors: one of these is long-term increased blood pressure—hypertension. Nitric oxide (NO) is a small nitrogenous radical species that has a number of physiological functions including vasodilation. It can be produced enzymatically through host nitric oxide synthases and by an alternative nitrate–nitrite–NO pathway from ingested inorganic nitrate. It was discovered that this route relies on the ability of the oral microbiota to reduce nitrate to nitrite and NO. Next generation sequencing has been used over the past two decades to gain deeper insight into the microbes involved, their location and the effect of their removal from the oral cavity. This review article presents this research and comments briefly on future directions.

AB - Cardiovascular disease is a worldwide human condition which has multiple underlying contributing factors: one of these is long-term increased blood pressure—hypertension. Nitric oxide (NO) is a small nitrogenous radical species that has a number of physiological functions including vasodilation. It can be produced enzymatically through host nitric oxide synthases and by an alternative nitrate–nitrite–NO pathway from ingested inorganic nitrate. It was discovered that this route relies on the ability of the oral microbiota to reduce nitrate to nitrite and NO. Next generation sequencing has been used over the past two decades to gain deeper insight into the microbes involved, their location and the effect of their removal from the oral cavity. This review article presents this research and comments briefly on future directions.

KW - oral microbiome

KW - saliva

KW - nitric oxide

KW - nitrate

KW - nitrite

U2 - 10.3390/jcm8081110

DO - 10.3390/jcm8081110

M3 - Review article

VL - 8

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

SN - 2077-0383

IS - 8

M1 - 1110

ER -