Next generation sequencing discoveries of the nitrate-responsive oral microbiome and its effect on vascular responses

Research output: Contribution to journalReview articlepeer-review

Authors

Colleges, School and Institutes

External organisations

  • Malmö University

Abstract

Cardiovascular disease is a worldwide human condition which has multiple underlying contributing factors: one of these is long-term increased blood pressure—hypertension. Nitric oxide (NO) is a small nitrogenous radical species that has a number of physiological functions including vasodilation. It can be produced enzymatically through host nitric oxide synthases and by an alternative nitrate–nitrite–NO pathway from ingested inorganic nitrate. It was discovered that this route relies on the ability of the oral microbiota to reduce nitrate to nitrite and NO. Next generation sequencing has been used over the past two decades to gain deeper insight into the microbes involved, their location and the effect of their removal from the oral cavity. This review article presents this research and comments briefly on future directions.

Details

Original languageEnglish
Article number1110
Number of pages9
JournalJournal of Clinical Medicine
Volume8
Issue number8
Publication statusPublished - 26 Jul 2019

Keywords

  • oral microbiome, saliva, nitric oxide, nitrate, nitrite

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