Next generation sequencing discoveries of the nitrate-responsive oral microbiome and its effect on vascular responses
Research output: Contribution to journal › Review article › peer-review
Authors
Colleges, School and Institutes
External organisations
- Malmö University
Abstract
Cardiovascular disease is a worldwide human condition which has multiple underlying contributing factors: one of these is long-term increased blood pressure—hypertension. Nitric oxide (NO) is a small nitrogenous radical species that has a number of physiological functions including vasodilation. It can be produced enzymatically through host nitric oxide synthases and by an alternative nitrate–nitrite–NO pathway from ingested inorganic nitrate. It was discovered that this route relies on the ability of the oral microbiota to reduce nitrate to nitrite and NO. Next generation sequencing has been used over the past two decades to gain deeper insight into the microbes involved, their location and the effect of their removal from the oral cavity. This review article presents this research and comments briefly on future directions.
Details
Original language | English |
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Article number | 1110 |
Number of pages | 9 |
Journal | Journal of Clinical Medicine |
Volume | 8 |
Issue number | 8 |
Publication status | Published - 26 Jul 2019 |
Keywords
- oral microbiome, saliva, nitric oxide, nitrate, nitrite