New ideas for non-animal approaches to predict repeated-dose systemic toxicity: report from an EPAA Blue Sky Workshop

Research output: Contribution to journalArticlepeer-review

Standard

New ideas for non-animal approaches to predict repeated-dose systemic toxicity : report from an EPAA Blue Sky Workshop. / Mahony, Catherine; Ashton, Randolph S.; Birk, Barbara; Boobis, Alan R.; Cull, Tom; Daston, George P.; Ewart, Lorna; Knudsen, Thomas B.; Manou, Irene; Maurer-Stroh, Sebastian; Margiotta-Casaluci, Luigi; Müller, Boris P.; Nordlund, Pär; Roberts, Ruth A.; Steger-Hartmann, Thomas; Vandenbossche, Evita; Viant, Mark R.; Vinken, Mathieu; Whelan, Maurice; Zvonimir, Zvonar; Cronin, Mark T.D.

In: Regulatory Toxicology and Pharmacology, Vol. 114, 104668, 07.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

Mahony, C, Ashton, RS, Birk, B, Boobis, AR, Cull, T, Daston, GP, Ewart, L, Knudsen, TB, Manou, I, Maurer-Stroh, S, Margiotta-Casaluci, L, Müller, BP, Nordlund, P, Roberts, RA, Steger-Hartmann, T, Vandenbossche, E, Viant, MR, Vinken, M, Whelan, M, Zvonimir, Z & Cronin, MTD 2020, 'New ideas for non-animal approaches to predict repeated-dose systemic toxicity: report from an EPAA Blue Sky Workshop', Regulatory Toxicology and Pharmacology, vol. 114, 104668. https://doi.org/10.1016/j.yrtph.2020.104668

APA

Mahony, C., Ashton, R. S., Birk, B., Boobis, A. R., Cull, T., Daston, G. P., Ewart, L., Knudsen, T. B., Manou, I., Maurer-Stroh, S., Margiotta-Casaluci, L., Müller, B. P., Nordlund, P., Roberts, R. A., Steger-Hartmann, T., Vandenbossche, E., Viant, M. R., Vinken, M., Whelan, M., ... Cronin, M. T. D. (2020). New ideas for non-animal approaches to predict repeated-dose systemic toxicity: report from an EPAA Blue Sky Workshop. Regulatory Toxicology and Pharmacology, 114, [104668]. https://doi.org/10.1016/j.yrtph.2020.104668

Vancouver

Author

Mahony, Catherine ; Ashton, Randolph S. ; Birk, Barbara ; Boobis, Alan R. ; Cull, Tom ; Daston, George P. ; Ewart, Lorna ; Knudsen, Thomas B. ; Manou, Irene ; Maurer-Stroh, Sebastian ; Margiotta-Casaluci, Luigi ; Müller, Boris P. ; Nordlund, Pär ; Roberts, Ruth A. ; Steger-Hartmann, Thomas ; Vandenbossche, Evita ; Viant, Mark R. ; Vinken, Mathieu ; Whelan, Maurice ; Zvonimir, Zvonar ; Cronin, Mark T.D. / New ideas for non-animal approaches to predict repeated-dose systemic toxicity : report from an EPAA Blue Sky Workshop. In: Regulatory Toxicology and Pharmacology. 2020 ; Vol. 114.

Bibtex

@article{102d6a4c68f84fc2b513d957bba3f0d8,
title = "New ideas for non-animal approaches to predict repeated-dose systemic toxicity: report from an EPAA Blue Sky Workshop",
abstract = "The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a {\textquoteleft}Blue Sky Workshop{\textquoteright} on new ideas for non-animal approaches to predict repeated-dose systemic toxicity. The aim of the Workshop was to formulate strategic ideas to improve and increase the applicability, implementation and acceptance of modern non-animal methods to determine systemic toxicity. The Workshop concluded that good progress is being made to assess repeated dose toxicity without animals taking advantage of existing knowledge in toxicology, thresholds of toxicological concern, adverse outcome pathways and read-across workflows. These approaches can be supported by New Approach Methodologies (NAMs) utilising modern molecular technologies and computational methods. Recommendations from the Workshop were based around the needs for better chemical safety assessment: how to strengthen the evidence base for decision making; to develop, standardise and harmonise NAMs for human toxicity; and the improvement in the applicability and acceptance of novel techniques. “Disruptive thinking” is required to reconsider chemical legislation, validation of NAMs and the opportunities to move away from reliance on animal tests. Case study practices and data sharing, ensuring reproducibility of NAMs, were viewed as crucial to the improvement of non-animal test approaches for systemic toxicity.",
keywords = "ab initio, Alternatives, Chemical legislation, in silico, in vitro, Read-across, Repeated dose toxicity testing, Safety assessment",
author = "Catherine Mahony and Ashton, {Randolph S.} and Barbara Birk and Boobis, {Alan R.} and Tom Cull and Daston, {George P.} and Lorna Ewart and Knudsen, {Thomas B.} and Irene Manou and Sebastian Maurer-Stroh and Luigi Margiotta-Casaluci and M{\"u}ller, {Boris P.} and P{\"a}r Nordlund and Roberts, {Ruth A.} and Thomas Steger-Hartmann and Evita Vandenbossche and Viant, {Mark R.} and Mathieu Vinken and Maurice Whelan and Zvonar Zvonimir and Cronin, {Mark T.D.}",
note = "Copyright {\textcopyright} 2020 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2020",
month = jul,
doi = "10.1016/j.yrtph.2020.104668",
language = "English",
volume = "114",
journal = "Regulatory Toxicology and Pharmacology",
issn = "0273-2300",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - New ideas for non-animal approaches to predict repeated-dose systemic toxicity

T2 - report from an EPAA Blue Sky Workshop

AU - Mahony, Catherine

AU - Ashton, Randolph S.

AU - Birk, Barbara

AU - Boobis, Alan R.

AU - Cull, Tom

AU - Daston, George P.

AU - Ewart, Lorna

AU - Knudsen, Thomas B.

AU - Manou, Irene

AU - Maurer-Stroh, Sebastian

AU - Margiotta-Casaluci, Luigi

AU - Müller, Boris P.

AU - Nordlund, Pär

AU - Roberts, Ruth A.

AU - Steger-Hartmann, Thomas

AU - Vandenbossche, Evita

AU - Viant, Mark R.

AU - Vinken, Mathieu

AU - Whelan, Maurice

AU - Zvonimir, Zvonar

AU - Cronin, Mark T.D.

N1 - Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2020/7

Y1 - 2020/7

N2 - The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a ‘Blue Sky Workshop’ on new ideas for non-animal approaches to predict repeated-dose systemic toxicity. The aim of the Workshop was to formulate strategic ideas to improve and increase the applicability, implementation and acceptance of modern non-animal methods to determine systemic toxicity. The Workshop concluded that good progress is being made to assess repeated dose toxicity without animals taking advantage of existing knowledge in toxicology, thresholds of toxicological concern, adverse outcome pathways and read-across workflows. These approaches can be supported by New Approach Methodologies (NAMs) utilising modern molecular technologies and computational methods. Recommendations from the Workshop were based around the needs for better chemical safety assessment: how to strengthen the evidence base for decision making; to develop, standardise and harmonise NAMs for human toxicity; and the improvement in the applicability and acceptance of novel techniques. “Disruptive thinking” is required to reconsider chemical legislation, validation of NAMs and the opportunities to move away from reliance on animal tests. Case study practices and data sharing, ensuring reproducibility of NAMs, were viewed as crucial to the improvement of non-animal test approaches for systemic toxicity.

AB - The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a ‘Blue Sky Workshop’ on new ideas for non-animal approaches to predict repeated-dose systemic toxicity. The aim of the Workshop was to formulate strategic ideas to improve and increase the applicability, implementation and acceptance of modern non-animal methods to determine systemic toxicity. The Workshop concluded that good progress is being made to assess repeated dose toxicity without animals taking advantage of existing knowledge in toxicology, thresholds of toxicological concern, adverse outcome pathways and read-across workflows. These approaches can be supported by New Approach Methodologies (NAMs) utilising modern molecular technologies and computational methods. Recommendations from the Workshop were based around the needs for better chemical safety assessment: how to strengthen the evidence base for decision making; to develop, standardise and harmonise NAMs for human toxicity; and the improvement in the applicability and acceptance of novel techniques. “Disruptive thinking” is required to reconsider chemical legislation, validation of NAMs and the opportunities to move away from reliance on animal tests. Case study practices and data sharing, ensuring reproducibility of NAMs, were viewed as crucial to the improvement of non-animal test approaches for systemic toxicity.

KW - ab initio

KW - Alternatives

KW - Chemical legislation

KW - in silico

KW - in vitro

KW - Read-across

KW - Repeated dose toxicity testing

KW - Safety assessment

UR - http://www.scopus.com/inward/record.url?scp=85083897051&partnerID=8YFLogxK

U2 - 10.1016/j.yrtph.2020.104668

DO - 10.1016/j.yrtph.2020.104668

M3 - Article

C2 - 32335207

AN - SCOPUS:85083897051

VL - 114

JO - Regulatory Toxicology and Pharmacology

JF - Regulatory Toxicology and Pharmacology

SN - 0273-2300

M1 - 104668

ER -