New advances in CMV and immunosenescence

Paolo Sansoni; Rosanna Vescovini; Francesco F Fagnoni; Arne Akbar; Ramon Arens; Yen-Ling Chiu; Luka Cičin-Šain; Julie Dechanet-Merville; Evelyna Derhovanessian; Sara Ferrando-Martinez; Claudio Franceschi; Daniela Frasca; Tamas Fulöp; David Furman; Effrossyni Gkrania-Klotsas; Felicia Goodrum; Beatrix Grubeck-Loebenstein; Mikko Hurme; Florian Kern; Daniele Lilleri; Miguel López-Botet; Andrea B Maier; Thomas Marandu; Arnaud Marchant; Catharina Matheï; Paul Moss; Aura Muntasell; Ester B M Remmerswaal; Natalie E Riddell; Kathrin Rothe; Delphine Sauce; Eui-Cheol Shin; Amanda M Simanek; Megan J Smithey; Cecilia Söderberg-Nauclér; Rafael Solana; Paul G Thomas; Rene van Lier; Graham Pawelec; Janko Nikolich-Zugich

doi:10.1016/j.exger.2014.03.020

New advances in CMV and immunosenescence

Paolo Sansoni, Rosanna Vescovini, Francesco F Fagnoni, Arne Akbar, Ramon Arens, Yen-Ling Chiu, Luka Cičin-Šain, Julie Dechanet-Merville, Evelyna Derhovanessian, Sara Ferrando-Martinez, Claudio Franceschi, Daniela Frasca, Tamas Fulöp, David Furman, Effrossyni Gkrania-Klotsas, Felicia Goodrum, Beatrix Grubeck-Loebenstein, Mikko Hurme, Florian Kern, Daniele LilleriMiguel López-Botet, Andrea B Maier, Thomas Marandu, Arnaud Marchant, Catharina Matheï, Paul Moss, Aura Muntasell, Ester B M Remmerswaal, Natalie E Riddell, Kathrin Rothe, Delphine Sauce, Eui-Cheol Shin, Amanda M Simanek, Megan J Smithey, Cecilia Söderberg-Nauclér, Rafael Solana, Paul G Thomas, Rene van Lier, Graham Pawelec, Janko Nikolich-Zugich

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

96 Citations (Scopus)

Abstract

Immunosenescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterized by impaired protective immunity and decreased efficacy of vaccines. An increasing number of immunological, clinical and epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection is associated with accelerated aging of the immune system and with several age-related diseases. However, current evidence on whether and how human CMV (HCMV) infection is implicated in immunosenescence and in age-related diseases remains incomplete and many aspects of CMV involvement in immune aging remain controversial. The attendees of the 4th International Workshop on "CMV & Immunosenescence", held in Parma, Italy, 25-27th March, 2013, presented and discussed data related to these open questions, which are reported in this commentary.

Original language	English
Pages (from-to)	54-62
Number of pages	9
Journal	Experimental gerontology
Volume	55
DOIs	https://doi.org/10.1016/j.exger.2014.03.020
Publication status	Published - Jul 2014

Bibliographical note

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Sansoni, P., Vescovini, R., Fagnoni, F. F., Akbar, A., Arens, R., Chiu, Y-L., Cičin-Šain, L., Dechanet-Merville, J., Derhovanessian, E., Ferrando-Martinez, S., Franceschi, C., Frasca, D., Fulöp, T., Furman, D., Gkrania-Klotsas, E., Goodrum, F., Grubeck-Loebenstein, B., Hurme, M., Kern, F., ... Nikolich-Zugich, J. (2014). New advances in CMV and immunosenescence. Experimental gerontology, 55, 54-62. https://doi.org/10.1016/j.exger.2014.03.020

@article{dbd713adc1a949f799b18c76c73b0b7f,

title = "New advances in CMV and immunosenescence",

abstract = "Immunosenescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterized by impaired protective immunity and decreased efficacy of vaccines. An increasing number of immunological, clinical and epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection is associated with accelerated aging of the immune system and with several age-related diseases. However, current evidence on whether and how human CMV (HCMV) infection is implicated in immunosenescence and in age-related diseases remains incomplete and many aspects of CMV involvement in immune aging remain controversial. The attendees of the 4th International Workshop on {"}CMV & Immunosenescence{"}, held in Parma, Italy, 25-27th March, 2013, presented and discussed data related to these open questions, which are reported in this commentary.",

author = "Paolo Sansoni and Rosanna Vescovini and Fagnoni, {Francesco F} and Arne Akbar and Ramon Arens and Yen-Ling Chiu and Luka Ci{\v c}in-{\v S}ain and Julie Dechanet-Merville and Evelyna Derhovanessian and Sara Ferrando-Martinez and Claudio Franceschi and Daniela Frasca and Tamas Ful{\"o}p and David Furman and Effrossyni Gkrania-Klotsas and Felicia Goodrum and Beatrix Grubeck-Loebenstein and Mikko Hurme and Florian Kern and Daniele Lilleri and Miguel L{\'o}pez-Botet and Maier, {Andrea B} and Thomas Marandu and Arnaud Marchant and Catharina Mathe{\"i} and Paul Moss and Aura Muntasell and Remmerswaal, {Ester B M} and Riddell, {Natalie E} and Kathrin Rothe and Delphine Sauce and Eui-Cheol Shin and Simanek, {Amanda M} and Smithey, {Megan J} and Cecilia S{\"o}derberg-Naucl{\'e}r and Rafael Solana and Thomas, {Paul G} and {van Lier}, Rene and Graham Pawelec and Janko Nikolich-Zugich",

note = "Copyright {\textcopyright} 2014. Published by Elsevier Inc.",

year = "2014",

month = jul,

doi = "10.1016/j.exger.2014.03.020",

language = "English",

volume = "55",

pages = "54--62",

journal = "Experimental gerontology",

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Sansoni, P, Vescovini, R, Fagnoni, FF, Akbar, A, Arens, R, Chiu, Y-L, Cičin-Šain, L, Dechanet-Merville, J, Derhovanessian, E, Ferrando-Martinez, S, Franceschi, C, Frasca, D, Fulöp, T, Furman, D, Gkrania-Klotsas, E, Goodrum, F, Grubeck-Loebenstein, B, Hurme, M, Kern, F, Lilleri, D, López-Botet, M, Maier, AB, Marandu, T, Marchant, A, Matheï, C, Moss, P, Muntasell, A, Remmerswaal, EBM, Riddell, NE, Rothe, K, Sauce, D, Shin, E-C, Simanek, AM, Smithey, MJ, Söderberg-Nauclér, C, Solana, R, Thomas, PG, van Lier, R, Pawelec, G & Nikolich-Zugich, J 2014, 'New advances in CMV and immunosenescence', Experimental gerontology, vol. 55, pp. 54-62. https://doi.org/10.1016/j.exger.2014.03.020

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T1 - New advances in CMV and immunosenescence

AU - Sansoni, Paolo

AU - Vescovini, Rosanna

AU - Fagnoni, Francesco F

AU - Akbar, Arne

AU - Arens, Ramon

AU - Chiu, Yen-Ling

AU - Cičin-Šain, Luka

AU - Dechanet-Merville, Julie

AU - Derhovanessian, Evelyna

AU - Ferrando-Martinez, Sara

AU - Franceschi, Claudio

AU - Frasca, Daniela

AU - Fulöp, Tamas

AU - Furman, David

AU - Gkrania-Klotsas, Effrossyni

AU - Goodrum, Felicia

AU - Grubeck-Loebenstein, Beatrix

AU - Hurme, Mikko

AU - Kern, Florian

AU - Lilleri, Daniele

AU - López-Botet, Miguel

AU - Maier, Andrea B

AU - Marandu, Thomas

AU - Marchant, Arnaud

AU - Matheï, Catharina

AU - Moss, Paul

AU - Muntasell, Aura

AU - Remmerswaal, Ester B M

AU - Riddell, Natalie E

AU - Rothe, Kathrin

AU - Sauce, Delphine

AU - Shin, Eui-Cheol

AU - Simanek, Amanda M

AU - Smithey, Megan J

AU - Söderberg-Nauclér, Cecilia

AU - Solana, Rafael

AU - Thomas, Paul G

AU - van Lier, Rene

AU - Pawelec, Graham

AU - Nikolich-Zugich, Janko

PY - 2014/7

Y1 - 2014/7

N2 - Immunosenescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterized by impaired protective immunity and decreased efficacy of vaccines. An increasing number of immunological, clinical and epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection is associated with accelerated aging of the immune system and with several age-related diseases. However, current evidence on whether and how human CMV (HCMV) infection is implicated in immunosenescence and in age-related diseases remains incomplete and many aspects of CMV involvement in immune aging remain controversial. The attendees of the 4th International Workshop on "CMV & Immunosenescence", held in Parma, Italy, 25-27th March, 2013, presented and discussed data related to these open questions, which are reported in this commentary.

AB - Immunosenescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterized by impaired protective immunity and decreased efficacy of vaccines. An increasing number of immunological, clinical and epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection is associated with accelerated aging of the immune system and with several age-related diseases. However, current evidence on whether and how human CMV (HCMV) infection is implicated in immunosenescence and in age-related diseases remains incomplete and many aspects of CMV involvement in immune aging remain controversial. The attendees of the 4th International Workshop on "CMV & Immunosenescence", held in Parma, Italy, 25-27th March, 2013, presented and discussed data related to these open questions, which are reported in this commentary.

U2 - 10.1016/j.exger.2014.03.020

DO - 10.1016/j.exger.2014.03.020

M3 - Article

C2 - 24703889

SN - 0531-5565

VL - 55

SP - 54

EP - 62

JO - Experimental gerontology

JF - Experimental gerontology

ER -

New advances in CMV and immunosenescence

Abstract

Bibliographical note

UN SDGs

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