TY - JOUR
T1 - Neutrophil ageing and immunesenescene
AU - Lord, Janet
AU - Butcher, Stephen
AU - Killampali, V
AU - Lascelles, David
AU - Salmon, Michael
PY - 2001/9/30
Y1 - 2001/9/30
N2 - As humans age, their morbidity and mortality from infection increases, their response to vaccination declines and they have an increased incidence of inflammatory diseases and cancer. The reasons for these effects are clearly complex, but reduced efficiency of the innate and adaptive immune system is likely to be important in the pathology of old age. Age-related changes in the adaptive immune system are well-documented and include alterations in T cell phenotype and effector functions and a reduced ability of B cells to produce high affinity antibody. In contrast, the innate immune system has been less well researched and the perception amongst many immunogerontologists is that this branch of the immune system is only moderately affected by age. However, it is becoming increasingly clear that the adaptive and innate immune systems co-operate at several levels to ensure the optimal immune response and any decline in adaptive immunity will impact upon the function of the innate immune system and vice-versa. Here, we review the literature concerning intrinsic age-related changes in neutrophil responses and consider how changes in lymphocyte function with age might further compromise efficiency of neutrophil function. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
AB - As humans age, their morbidity and mortality from infection increases, their response to vaccination declines and they have an increased incidence of inflammatory diseases and cancer. The reasons for these effects are clearly complex, but reduced efficiency of the innate and adaptive immune system is likely to be important in the pathology of old age. Age-related changes in the adaptive immune system are well-documented and include alterations in T cell phenotype and effector functions and a reduced ability of B cells to produce high affinity antibody. In contrast, the innate immune system has been less well researched and the perception amongst many immunogerontologists is that this branch of the immune system is only moderately affected by age. However, it is becoming increasingly clear that the adaptive and innate immune systems co-operate at several levels to ensure the optimal immune response and any decline in adaptive immunity will impact upon the function of the innate immune system and vice-versa. Here, we review the literature concerning intrinsic age-related changes in neutrophil responses and consider how changes in lymphocyte function with age might further compromise efficiency of neutrophil function. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
KW - immune
KW - infection
KW - vaccination
UR - http://www.scopus.com/inward/record.url?scp=0035975703&partnerID=8YFLogxK
U2 - 10.1016/S0047-6374(01)00285-8
DO - 10.1016/S0047-6374(01)00285-8
M3 - Article
C2 - 11511394
VL - 122
SP - 1521
EP - 1535
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
IS - 14
ER -