Neuroretinal cell death in a murine model of closed globe injury: pathological and functional characterization

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Neuroretinal cell death in a murine model of closed globe injury : pathological and functional characterization. / Blanch, Richard J; Ahmed, Zubair; Sik, Attila; Snead, David R J; Good, Peter A; O'Neill, Jenna; Berry, Martin; Scott, Robert A H; Logan, Ann.

In: Investigative Ophthalmology & Visual Science (IOVS), Vol. 53, No. 11, 2012, p. 7220-6.

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@article{865c14bd9962467da4c19b2aec243bff,
title = "Neuroretinal cell death in a murine model of closed globe injury: pathological and functional characterization",
abstract = "Blunt ocular trauma causes severe retinal injury with death of neuroretinal tissue, scarring, and permanent visual loss. The mechanisms of cell death are not known, and there are no therapeutic interventions that improve visual outcome. We aimed to study the extent, distribution, and functional consequences of cell death by developing and characterizing a rat model of retinal injury caused by blunt ocular trauma.",
author = "Blanch, {Richard J} and Zubair Ahmed and Attila Sik and Snead, {David R J} and Good, {Peter A} and Jenna O'Neill and Martin Berry and Scott, {Robert A H} and Ann Logan",
year = "2012",
doi = "10.1167/iovs.12-9887",
language = "English",
volume = "53",
pages = "7220--6",
journal = "Investigative Ophthalmology & Visual Science (IOVS)",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology",
number = "11",

}

RIS

TY - JOUR

T1 - Neuroretinal cell death in a murine model of closed globe injury

T2 - pathological and functional characterization

AU - Blanch, Richard J

AU - Ahmed, Zubair

AU - Sik, Attila

AU - Snead, David R J

AU - Good, Peter A

AU - O'Neill, Jenna

AU - Berry, Martin

AU - Scott, Robert A H

AU - Logan, Ann

PY - 2012

Y1 - 2012

N2 - Blunt ocular trauma causes severe retinal injury with death of neuroretinal tissue, scarring, and permanent visual loss. The mechanisms of cell death are not known, and there are no therapeutic interventions that improve visual outcome. We aimed to study the extent, distribution, and functional consequences of cell death by developing and characterizing a rat model of retinal injury caused by blunt ocular trauma.

AB - Blunt ocular trauma causes severe retinal injury with death of neuroretinal tissue, scarring, and permanent visual loss. The mechanisms of cell death are not known, and there are no therapeutic interventions that improve visual outcome. We aimed to study the extent, distribution, and functional consequences of cell death by developing and characterizing a rat model of retinal injury caused by blunt ocular trauma.

U2 - 10.1167/iovs.12-9887

DO - 10.1167/iovs.12-9887

M3 - Article

C2 - 22977137

VL - 53

SP - 7220

EP - 7226

JO - Investigative Ophthalmology & Visual Science (IOVS)

JF - Investigative Ophthalmology & Visual Science (IOVS)

SN - 0146-0404

IS - 11

ER -