Neuroretinal cell death in a murine model of closed globe injury: pathological and functional characterization

Richard J Blanch; Zubair Ahmed; Attila Sik; David R J Snead; Peter A Good; Jenna O'Neill; Martin Berry; Robert A H Scott; Ann Logan

doi:10.1167/iovs.12-9887

Neuroretinal cell death in a murine model of closed globe injury: pathological and functional characterization

Richard J Blanch, Zubair Ahmed, Attila Sik, David R J Snead, Peter A Good, Jenna O'Neill, Martin Berry, Robert A H Scott, Ann Logan

Birmingham Medical School

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Blunt ocular trauma causes severe retinal injury with death of neuroretinal tissue, scarring, and permanent visual loss. The mechanisms of cell death are not known, and there are no therapeutic interventions that improve visual outcome. We aimed to study the extent, distribution, and functional consequences of cell death by developing and characterizing a rat model of retinal injury caused by blunt ocular trauma.

Original language	English
Pages (from-to)	7220-6
Number of pages	7
Journal	Investigative Ophthalmology & Visual Science (IOVS)
Volume	53
Issue number	11
DOIs	https://doi.org/10.1167/iovs.12-9887
Publication status	Published - 2012

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10.1167/iovs.12-9887

Importance of Long-Range Inhibitory Connections in Hippocampal Network Oscillations
Sik, A.
Medical Research Council
1/10/11 → 30/09/15
Project: Research Councils

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abstract = "Blunt ocular trauma causes severe retinal injury with death of neuroretinal tissue, scarring, and permanent visual loss. The mechanisms of cell death are not known, and there are no therapeutic interventions that improve visual outcome. We aimed to study the extent, distribution, and functional consequences of cell death by developing and characterizing a rat model of retinal injury caused by blunt ocular trauma.",

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AU - Blanch, Richard J

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AU - Sik, Attila

AU - Snead, David R J

AU - Good, Peter A

AU - O'Neill, Jenna

AU - Berry, Martin

AU - Scott, Robert A H

AU - Logan, Ann

PY - 2012

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AB - Blunt ocular trauma causes severe retinal injury with death of neuroretinal tissue, scarring, and permanent visual loss. The mechanisms of cell death are not known, and there are no therapeutic interventions that improve visual outcome. We aimed to study the extent, distribution, and functional consequences of cell death by developing and characterizing a rat model of retinal injury caused by blunt ocular trauma.

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DO - 10.1167/iovs.12-9887

M3 - Article

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SN - 1552-5783

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EP - 7226

JO - Investigative Ophthalmology & Visual Science (IOVS)

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ER -

Neuroretinal cell death in a murine model of closed globe injury: pathological and functional characterization

Abstract

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Importance of Long-Range Inhibitory Connections in Hippocampal Network Oscillations

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