Neuroretinal cell death in a murine model of closed globe injury: pathological and functional characterization

Research output: Contribution to journalArticle

Authors

  • Richard J Blanch
  • David R J Snead
  • Peter A Good
  • Martin Berry
  • Robert A H Scott

Colleges, School and Institutes

Abstract

Blunt ocular trauma causes severe retinal injury with death of neuroretinal tissue, scarring, and permanent visual loss. The mechanisms of cell death are not known, and there are no therapeutic interventions that improve visual outcome. We aimed to study the extent, distribution, and functional consequences of cell death by developing and characterizing a rat model of retinal injury caused by blunt ocular trauma.

Details

Original languageEnglish
Pages (from-to)7220-6
Number of pages7
JournalInvestigative Ophthalmology & Visual Science (IOVS)
Volume53
Issue number11
Publication statusPublished - 2012