Neuropsychiatric manifestations in inflammatory neuropathies: A systematic review

Research output: Contribution to journalReview articlepeer-review


  • Yusuf A Rajabally
  • Stefano Seri
  • Andrea E Cavanna

External organisations

  • Aston University


We conducted a systematic literature review on psychological and behavioral comorbidities in patients with inflammatory neuropathies. In Guillain-Barré syndrome (GBS), psychotic symptoms are reported during early stages in 30% of patients. Typical associations include mechanical ventilation, autonomic dysfunction, inability to communicate, and severe weakness. Anxiety and depression are frequent comorbidities. Anxiety may increase post-hospital admissions and be a predictor of mechanical ventilation. Posttraumatic stress disorder may affect up to 20% of ventilated patients. Sleep disturbances are common in early-stage GBS, affecting up to 50% of patients. In chronic inflammatory demyelinating polyradiculoneuropathy, memory and quality of sleep may be impaired. An independent link between depression and pretreatment upper limb disability and ascites was reported in POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, skin) syndrome, with an association with early death. Hematological treatment of POEMS appears effective on depression. Published literature on psychological/behavioral manifestations in inflammatory neuropathies remains scarce, and further research is needed. Muscle Nerve 54: 1-8, 2016.


Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalMuscle & Nerve
Issue number1
Publication statusPublished - Jun 2016
Externally publishedYes


  • Databases, Bibliographic/statistics & numerical data, Guillain-Barre Syndrome/epidemiology, Humans, Mood Disorders/epidemiology, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/epidemiology, Psychotic Disorders/epidemiology, Sleep Wake Disorders/epidemiology