Neurobiological and behavioural studies of affective instability in clinical populations: a systematic review

Matthew R Broome; Zhimin He; Mashal Iftikhar; Julie Eyden; Steven Marwaha

doi:10.1016/j.neubiorev.2015.01.021

Neurobiological and behavioural studies of affective instability in clinical populations: a systematic review

Matthew R Broome, Zhimin He, Mashal Iftikhar, Julie Eyden, Steven Marwaha

Life and Environmental Sciences

Research output: Contribution to journal › Review article › peer-review

32 Citations (Scopus)

Abstract

OBJECTIVES: To evaluate the neurobiological, psychophysical and behavioural measures of affective instability in clinical populations.

DATA SOURCES: A range of medical and psychological science electronic databases were searched (including MEDLINE, EMBASE, and PsycINFO). Hand searching and reference checking are also included.

REVIEW METHODS: Reviews, systematic reviews, experimental and cross-sectional studies, providing affective instability in neurobiological and behavioural measurements in clinical populations. Studies were selected, data were extracted and quality was appraised.

RESULTS: Twenty-nine studies were included, 6 of which were review studies (one a meta-analysis) and 23 of which were primary studies, across a wide variety of disorders including ADHD, bipolar affective disorder, schizophrenia, severe mood dysregulation, major depression, and borderline personality disorder.

CONCLUSIONS: The bulk of the studies converge on the role of the amygdala, particularly in borderline personality disorders, and how it connects with other areas of the brain. Future research needs to extend these findings across diagnoses and development.

Original language	English
Pages (from-to)	243-254
Number of pages	12
Journal	Neuroscience and biobehavioral reviews
Volume	51
Early online date	4 Feb 2015
DOIs	https://doi.org/10.1016/j.neubiorev.2015.01.021
Publication status	Published - 1 Apr 2015

Bibliographical note

Print-Electronic

Keywords

Brain/physiopathology
Humans
Mood Disorders/physiopathology

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Cite this

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title = "Neurobiological and behavioural studies of affective instability in clinical populations: a systematic review",

abstract = "OBJECTIVES: To evaluate the neurobiological, psychophysical and behavioural measures of affective instability in clinical populations.DATA SOURCES: A range of medical and psychological science electronic databases were searched (including MEDLINE, EMBASE, and PsycINFO). Hand searching and reference checking are also included.REVIEW METHODS: Reviews, systematic reviews, experimental and cross-sectional studies, providing affective instability in neurobiological and behavioural measurements in clinical populations. Studies were selected, data were extracted and quality was appraised.RESULTS: Twenty-nine studies were included, 6 of which were review studies (one a meta-analysis) and 23 of which were primary studies, across a wide variety of disorders including ADHD, bipolar affective disorder, schizophrenia, severe mood dysregulation, major depression, and borderline personality disorder.CONCLUSIONS: The bulk of the studies converge on the role of the amygdala, particularly in borderline personality disorders, and how it connects with other areas of the brain. Future research needs to extend these findings across diagnoses and development.",

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T2 - a systematic review

AU - Broome, Matthew R

AU - He, Zhimin

AU - Iftikhar, Mashal

AU - Eyden, Julie

AU - Marwaha, Steven

N1 - Print-Electronic

PY - 2015/4/1

Y1 - 2015/4/1

N2 - OBJECTIVES: To evaluate the neurobiological, psychophysical and behavioural measures of affective instability in clinical populations.DATA SOURCES: A range of medical and psychological science electronic databases were searched (including MEDLINE, EMBASE, and PsycINFO). Hand searching and reference checking are also included.REVIEW METHODS: Reviews, systematic reviews, experimental and cross-sectional studies, providing affective instability in neurobiological and behavioural measurements in clinical populations. Studies were selected, data were extracted and quality was appraised.RESULTS: Twenty-nine studies were included, 6 of which were review studies (one a meta-analysis) and 23 of which were primary studies, across a wide variety of disorders including ADHD, bipolar affective disorder, schizophrenia, severe mood dysregulation, major depression, and borderline personality disorder.CONCLUSIONS: The bulk of the studies converge on the role of the amygdala, particularly in borderline personality disorders, and how it connects with other areas of the brain. Future research needs to extend these findings across diagnoses and development.

AB - OBJECTIVES: To evaluate the neurobiological, psychophysical and behavioural measures of affective instability in clinical populations.DATA SOURCES: A range of medical and psychological science electronic databases were searched (including MEDLINE, EMBASE, and PsycINFO). Hand searching and reference checking are also included.REVIEW METHODS: Reviews, systematic reviews, experimental and cross-sectional studies, providing affective instability in neurobiological and behavioural measurements in clinical populations. Studies were selected, data were extracted and quality was appraised.RESULTS: Twenty-nine studies were included, 6 of which were review studies (one a meta-analysis) and 23 of which were primary studies, across a wide variety of disorders including ADHD, bipolar affective disorder, schizophrenia, severe mood dysregulation, major depression, and borderline personality disorder.CONCLUSIONS: The bulk of the studies converge on the role of the amygdala, particularly in borderline personality disorders, and how it connects with other areas of the brain. Future research needs to extend these findings across diagnoses and development.

KW - Brain/physiopathology

KW - Humans

KW - Mood Disorders/physiopathology

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DO - 10.1016/j.neubiorev.2015.01.021

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SN - 0149-7634

VL - 51

SP - 243

EP - 254

JO - Neuroscience and biobehavioral reviews

JF - Neuroscience and biobehavioral reviews

ER -

Neurobiological and behavioural studies of affective instability in clinical populations: a systematic review

Abstract

Bibliographical note

Keywords

Access to Document

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Cite this