Neuroanatomical abnormalities that predate the onset of psychosis: a multicenter study

Andrea Mechelli; Anita Riecher-Rössler; Eva M Meisenzahl; Stefania Tognin; Stephen J Wood; Stefan J Borgwardt; Nikolaos Koutsouleris; Alison R Yung; James M Stone; Lisa J Phillips; Patrick D McGorry; Isabel Valli; Dennis Velakoulis; James Woolley; Christos Pantelis; Philip McGuire

doi:10.1001/archgenpsychiatry.2011.42

Neuroanatomical abnormalities that predate the onset of psychosis: a multicenter study

Andrea Mechelli, Anita Riecher-Rössler, Eva M Meisenzahl, Stefania Tognin, Stephen J Wood, Stefan J Borgwardt, Nikolaos Koutsouleris, Alison R Yung, James M Stone, Lisa J Phillips, Patrick D McGorry, Isabel Valli, Dennis Velakoulis, James Woolley, Christos Pantelis, Philip McGuire

Psychology

Research output: Contribution to journal › Article › peer-review

191 Citations (Scopus)

Abstract

People experiencing possible prodromal symptoms of psychosis have a very high risk of developing the disorder, but it is not possible to predict, on the basis of their presenting clinical features, which individuals will subsequently become psychotic. Recent neuroimaging studies suggest that there are volumetric differences between individuals at ultra-high risk (UHR) for psychosis who later develop psychotic disorder and those who do not. However, the samples examined to date have been small, and the findings have been inconsistent.

Original language	English
Pages (from-to)	489-95
Number of pages	7
Journal	Archives of General Psychiatry
Volume	68
Issue number	5
DOIs	https://doi.org/10.1001/archgenpsychiatry.2011.42
Publication status	Published - 2011

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Mechelli, A., Riecher-Rössler, A., Meisenzahl, E. M., Tognin, S., Wood, S. J., Borgwardt, S. J., Koutsouleris, N., Yung, A. R., Stone, J. M., Phillips, L. J., McGorry, P. D., Valli, I., Velakoulis, D., Woolley, J., Pantelis, C., & McGuire, P. (2011). Neuroanatomical abnormalities that predate the onset of psychosis: a multicenter study. Archives of General Psychiatry, 68(5), 489-95. https://doi.org/10.1001/archgenpsychiatry.2011.42

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abstract = "People experiencing possible prodromal symptoms of psychosis have a very high risk of developing the disorder, but it is not possible to predict, on the basis of their presenting clinical features, which individuals will subsequently become psychotic. Recent neuroimaging studies suggest that there are volumetric differences between individuals at ultra-high risk (UHR) for psychosis who later develop psychotic disorder and those who do not. However, the samples examined to date have been small, and the findings have been inconsistent.",

author = "Andrea Mechelli and Anita Riecher-R{\"o}ssler and Meisenzahl, {Eva M} and Stefania Tognin and Wood, {Stephen J} and Borgwardt, {Stefan J} and Nikolaos Koutsouleris and Yung, {Alison R} and Stone, {James M} and Phillips, {Lisa J} and McGorry, {Patrick D} and Isabel Valli and Dennis Velakoulis and James Woolley and Christos Pantelis and Philip McGuire",

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Mechelli, A, Riecher-Rössler, A, Meisenzahl, EM, Tognin, S, Wood, SJ, Borgwardt, SJ, Koutsouleris, N, Yung, AR, Stone, JM, Phillips, LJ, McGorry, PD, Valli, I, Velakoulis, D, Woolley, J, Pantelis, C & McGuire, P 2011, 'Neuroanatomical abnormalities that predate the onset of psychosis: a multicenter study', Archives of General Psychiatry, vol. 68, no. 5, pp. 489-95. https://doi.org/10.1001/archgenpsychiatry.2011.42

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T1 - Neuroanatomical abnormalities that predate the onset of psychosis

T2 - a multicenter study

AU - Mechelli, Andrea

AU - Riecher-Rössler, Anita

AU - Meisenzahl, Eva M

AU - Tognin, Stefania

AU - Wood, Stephen J

AU - Borgwardt, Stefan J

AU - Koutsouleris, Nikolaos

AU - Yung, Alison R

AU - Stone, James M

AU - Phillips, Lisa J

AU - McGorry, Patrick D

AU - Valli, Isabel

AU - Velakoulis, Dennis

AU - Woolley, James

AU - Pantelis, Christos

AU - McGuire, Philip

PY - 2011

Y1 - 2011

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AB - People experiencing possible prodromal symptoms of psychosis have a very high risk of developing the disorder, but it is not possible to predict, on the basis of their presenting clinical features, which individuals will subsequently become psychotic. Recent neuroimaging studies suggest that there are volumetric differences between individuals at ultra-high risk (UHR) for psychosis who later develop psychotic disorder and those who do not. However, the samples examined to date have been small, and the findings have been inconsistent.

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DO - 10.1001/archgenpsychiatry.2011.42

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SP - 489

EP - 495

JO - Archives of General Psychiatry

JF - Archives of General Psychiatry

IS - 5

ER -

Neuroanatomical abnormalities that predate the onset of psychosis: a multicenter study

Abstract

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