Neural correlates of theory of mind in typically-developing youth: influence of sex, age and callous-unemotional traits

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Neural correlates of theory of mind in typically-developing youth : influence of sex, age and callous-unemotional traits. / Gao, Yidian; Rogers, Jack; Pauli, Ruth; Clanton, Roberta; Baker, Rosalind; Birch, Philippa; Ferreira, Lisandra; Brown, Abigail; Freitag, Christine M.; Fairchild, Graeme; Rotshtein, Pia; De Brito, Stephane.

In: Scientific Reports, Vol. 9, No. 1, 16216 , 07.11.2019.

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Gao, Yidian ; Rogers, Jack ; Pauli, Ruth ; Clanton, Roberta ; Baker, Rosalind ; Birch, Philippa ; Ferreira, Lisandra ; Brown, Abigail ; Freitag, Christine M. ; Fairchild, Graeme ; Rotshtein, Pia ; De Brito, Stephane. / Neural correlates of theory of mind in typically-developing youth : influence of sex, age and callous-unemotional traits. In: Scientific Reports. 2019 ; Vol. 9, No. 1.

Bibtex

@article{8d152b42e9764955aed49d1d95c0353d,
title = "Neural correlates of theory of mind in typically-developing youth: influence of sex, age and callous-unemotional traits",
abstract = "Theory of mind (ToM), or the ability to infer and predict the intentions, thoughts and beliefs of others, involves cognitive perspective taking (cognitive ToM/cToM) and understanding emotions (affective ToM/aToM). While behavioral evidence indicates that ToM is influenced by sex and age, no study has examined the influence of these variables on the neural correlates of cToM and aToM in late childhood/adolescence. Using fMRI with 35 typically-developing youths (aged 9-18 years, 12 males), we investigated the influence of sex and age on the neural correlates of cToM and aToM. We also examined how callous-unemotional traits, indexing a lack of empathy, were related to brain responses during aToM. Across both conditions, we found convergent activity in ToM network regions, such as superior temporal sulcus/temporoparietal junction (TPJ) and precuneus across males and females, but males recruited the left TPJ significantly more than females during cToM. During aToM, age was negatively correlated with brain responses in frontal, temporal and posterior midline regions, while callous-unemotional traits were positively correlated with right anterior insula responses. These results provide the first evidence in youth that sex influences the neural correlates of cToM, while age and callous-unemotional traits are specifically related to brain responses during aToM.",
author = "Yidian Gao and Jack Rogers and Ruth Pauli and Roberta Clanton and Rosalind Baker and Philippa Birch and Lisandra Ferreira and Abigail Brown and Freitag, {Christine M.} and Graeme Fairchild and Pia Rotshtein and {De Brito}, Stephane",
year = "2019",
month = nov
day = "7",
doi = "10.1038/s41598-019-52261-y",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Neural correlates of theory of mind in typically-developing youth

T2 - influence of sex, age and callous-unemotional traits

AU - Gao, Yidian

AU - Rogers, Jack

AU - Pauli, Ruth

AU - Clanton, Roberta

AU - Baker, Rosalind

AU - Birch, Philippa

AU - Ferreira, Lisandra

AU - Brown, Abigail

AU - Freitag, Christine M.

AU - Fairchild, Graeme

AU - Rotshtein, Pia

AU - De Brito, Stephane

PY - 2019/11/7

Y1 - 2019/11/7

N2 - Theory of mind (ToM), or the ability to infer and predict the intentions, thoughts and beliefs of others, involves cognitive perspective taking (cognitive ToM/cToM) and understanding emotions (affective ToM/aToM). While behavioral evidence indicates that ToM is influenced by sex and age, no study has examined the influence of these variables on the neural correlates of cToM and aToM in late childhood/adolescence. Using fMRI with 35 typically-developing youths (aged 9-18 years, 12 males), we investigated the influence of sex and age on the neural correlates of cToM and aToM. We also examined how callous-unemotional traits, indexing a lack of empathy, were related to brain responses during aToM. Across both conditions, we found convergent activity in ToM network regions, such as superior temporal sulcus/temporoparietal junction (TPJ) and precuneus across males and females, but males recruited the left TPJ significantly more than females during cToM. During aToM, age was negatively correlated with brain responses in frontal, temporal and posterior midline regions, while callous-unemotional traits were positively correlated with right anterior insula responses. These results provide the first evidence in youth that sex influences the neural correlates of cToM, while age and callous-unemotional traits are specifically related to brain responses during aToM.

AB - Theory of mind (ToM), or the ability to infer and predict the intentions, thoughts and beliefs of others, involves cognitive perspective taking (cognitive ToM/cToM) and understanding emotions (affective ToM/aToM). While behavioral evidence indicates that ToM is influenced by sex and age, no study has examined the influence of these variables on the neural correlates of cToM and aToM in late childhood/adolescence. Using fMRI with 35 typically-developing youths (aged 9-18 years, 12 males), we investigated the influence of sex and age on the neural correlates of cToM and aToM. We also examined how callous-unemotional traits, indexing a lack of empathy, were related to brain responses during aToM. Across both conditions, we found convergent activity in ToM network regions, such as superior temporal sulcus/temporoparietal junction (TPJ) and precuneus across males and females, but males recruited the left TPJ significantly more than females during cToM. During aToM, age was negatively correlated with brain responses in frontal, temporal and posterior midline regions, while callous-unemotional traits were positively correlated with right anterior insula responses. These results provide the first evidence in youth that sex influences the neural correlates of cToM, while age and callous-unemotional traits are specifically related to brain responses during aToM.

UR - http://www.scopus.com/inward/record.url?scp=85074686978&partnerID=8YFLogxK

U2 - 10.1038/s41598-019-52261-y

DO - 10.1038/s41598-019-52261-y

M3 - Article

C2 - 31700004

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 16216

ER -