Neural circuitry of novelty salience processing in psychosis risk: association with clinical outcome

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Neural circuitry of novelty salience processing in psychosis risk : association with clinical outcome. / Modinos, Gemma; Broome, Matthew; McGuire, PK.

In: Schizophrenia bulletin, 18.09.2019.

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@article{9c21182df9f64a87bba3843159d0d85e,
title = "Neural circuitry of novelty salience processing in psychosis risk: association with clinical outcome",
abstract = "Psychosis has been proposed to develop from dysfunction in a hippocampal-striatal-midbrain circuit, leading to aberrant salience processing. Here, we used functional magnetic resonance imaging (fMRI) during novelty salience processing to investigate this model in people at clinical high risk (CHR) for psychosis according to their subsequent clinical outcomes. Seventy-six CHR participants as defined using the Comprehensive Assessment of At-Risk Mental States (CAARMS) and 31 healthy controls (HC) were studied while performing a novelty salience fMRI task that engaged an a priori hippocampal-striatal-midbrain circuit of interest. The CHR sample was then followed clinically for a mean of 59.7 months (~5 y), when clinical outcomes were assessed in terms of transition (CHR-T) or non-transition (CHR-NT) to psychosis (CAARMS criteria): during this period, 13 individuals (17%) developed a psychotic …",
keywords = "psychosis, prodrome, fMRI, hippocampus, salience, schizophrenia",
author = "Gemma Modinos and Matthew Broome and PK McGuire",
year = "2019",
month = sep,
day = "18",
doi = "10.1093/schbul/sbz089",
language = "English",
journal = "Schizophrenia bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Neural circuitry of novelty salience processing in psychosis risk

T2 - association with clinical outcome

AU - Modinos, Gemma

AU - Broome, Matthew

AU - McGuire, PK

PY - 2019/9/18

Y1 - 2019/9/18

N2 - Psychosis has been proposed to develop from dysfunction in a hippocampal-striatal-midbrain circuit, leading to aberrant salience processing. Here, we used functional magnetic resonance imaging (fMRI) during novelty salience processing to investigate this model in people at clinical high risk (CHR) for psychosis according to their subsequent clinical outcomes. Seventy-six CHR participants as defined using the Comprehensive Assessment of At-Risk Mental States (CAARMS) and 31 healthy controls (HC) were studied while performing a novelty salience fMRI task that engaged an a priori hippocampal-striatal-midbrain circuit of interest. The CHR sample was then followed clinically for a mean of 59.7 months (~5 y), when clinical outcomes were assessed in terms of transition (CHR-T) or non-transition (CHR-NT) to psychosis (CAARMS criteria): during this period, 13 individuals (17%) developed a psychotic …

AB - Psychosis has been proposed to develop from dysfunction in a hippocampal-striatal-midbrain circuit, leading to aberrant salience processing. Here, we used functional magnetic resonance imaging (fMRI) during novelty salience processing to investigate this model in people at clinical high risk (CHR) for psychosis according to their subsequent clinical outcomes. Seventy-six CHR participants as defined using the Comprehensive Assessment of At-Risk Mental States (CAARMS) and 31 healthy controls (HC) were studied while performing a novelty salience fMRI task that engaged an a priori hippocampal-striatal-midbrain circuit of interest. The CHR sample was then followed clinically for a mean of 59.7 months (~5 y), when clinical outcomes were assessed in terms of transition (CHR-T) or non-transition (CHR-NT) to psychosis (CAARMS criteria): during this period, 13 individuals (17%) developed a psychotic …

KW - psychosis

KW - prodrome

KW - fMRI

KW - hippocampus

KW - salience

KW - schizophrenia

UR - https://doi.org/10.1093/schbul/sbz089

U2 - 10.1093/schbul/sbz089

DO - 10.1093/schbul/sbz089

M3 - Article

JO - Schizophrenia bulletin

JF - Schizophrenia bulletin

SN - 0586-7614

ER -