Neural circuitry of novelty salience processing in psychosis risk: association with clinical outcome

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

External organisations

  • King's College London
  • Kings Coll London

Abstract

Psychosis has been proposed to develop from dysfunction in a hippocampal-striatal-midbrain circuit, leading to aberrant salience processing. Here, we used functional magnetic resonance imaging (fMRI) during novelty salience processing to investigate this model in people at clinical high risk (CHR) for psychosis according to their subsequent clinical outcomes. Seventy-six CHR participants as defined using the Comprehensive Assessment of At-Risk Mental States (CAARMS) and 31 healthy controls (HC) were studied while performing a novelty salience fMRI task that engaged an a priori hippocampal-striatal-midbrain circuit of interest. The CHR sample was then followed clinically for a mean of 59.7 months (~5 y), when clinical outcomes were assessed in terms of transition (CHR-T) or non-transition (CHR-NT) to psychosis (CAARMS criteria): during this period, 13 individuals (17%) developed a psychotic …

Details

Original languageEnglish
JournalSchizophrenia bulletin
Publication statusPublished - 18 Sep 2019

Keywords

  • psychosis, prodrome, fMRI, hippocampus, salience, schizophrenia