Network topology and dynamics in traumatic brain injury

Research output: Contribution to journalArticlepeer-review

Authors

  • Aron K. Barbey
  • Rachael Rubin
  • Marta Zamroziewicz
  • Joachim T. Operskalski

Colleges, School and Institutes

External organisations

  • University of Illinois
  • Carle Foundation Hospital

Abstract

We propose a network approach to clinical translation that defines core behavioral phenotypes of traumatic brain injury (TBI) with respect to damage to specific intrinsic connectivity networks (ICNs). We survey recent approaches to clinical translation from cognitive neuroscience that enhance network function and recovery from brain injury through interventions that deliver targeted (network specific) and global (systemic) effects. A network approach provides insight into the mechanisms of brain injury, linking ICN characteristics to specific profiles of cognitive impairment, providing key neurobiological targets for therapeutic intervention, and motivating new perspectives about the nature of cognitive recovery and rehabilitation in TBI.

Details

Original languageEnglish
Pages (from-to)92-102
Number of pages11
JournalCurrent Opinion in Behavioral Sciences
Volume4
Early online date24 Apr 2015
Publication statusPublished - 1 Aug 2015