Neonatal and adult CD4+CD3- cells share similar gene expression profile, and neonatal cells upregulate OX40-ligand in response to TL1A (TNFSF15)

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@article{787c273cb89d48ac889d7d907553093a,
title = "Neonatal and adult CD4+CD3- cells share similar gene expression profile, and neonatal cells upregulate OX40-ligand in response to TL1A (TNFSF15)",
abstract = "We report here the quantitative expression of a set of immunity-related genes, including TNF family members, chemokine receptors, and transcription factors, in a CD4(+)CD3(-) accessory cell. By correlating gene expression between cell-sorted populations of defined phenotype, we show that the genetic fingerprint of these CD4(+)CD3(-) cells is distinct from dendritic cells, plasmacytoid dendritic cells, T cells, B cells, and NK cells. In contrast, it is highly similar to CD4(+)CD3(-) cells isolated from embryonic and neonatal tissues, with the exception that only adult populations express OX40L and CD30L. We have previously reported that IL-7 signals regulate CD30L expression. In the present study, we show that both neonatal and adult CD4(+)CD3(-) cells express the TNF family member, death receptor 3 (TNFRSF25), and that addition of TL1A (TNFSF15), the ligand for death receptor 3, up-regulates OX40L on neonatal CD4(+)CD3(-) cells. Finally, we demonstrate that this differentiation occurs in vivo: neonatal CD4(+)CD3(-) cells up-regulate both CD30L and OX40L after adoptive transfer into an adult recipient.",
author = "Mi-Yeon Kim and Kai-Michael Toellner and Andrea White and Fiona McConnell and Fabrina Gaspal and Sonia Parnell and Eric Jenkinson and Graham Anderson and Peter Lane",
year = "2006",
month = jan,
day = "1",
language = "English",
volume = "177",
pages = "3074--3081",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",

}

RIS

TY - JOUR

T1 - Neonatal and adult CD4+CD3- cells share similar gene expression profile, and neonatal cells upregulate OX40-ligand in response to TL1A (TNFSF15)

AU - Kim, Mi-Yeon

AU - Toellner, Kai-Michael

AU - White, Andrea

AU - McConnell, Fiona

AU - Gaspal, Fabrina

AU - Parnell, Sonia

AU - Jenkinson, Eric

AU - Anderson, Graham

AU - Lane, Peter

PY - 2006/1/1

Y1 - 2006/1/1

N2 - We report here the quantitative expression of a set of immunity-related genes, including TNF family members, chemokine receptors, and transcription factors, in a CD4(+)CD3(-) accessory cell. By correlating gene expression between cell-sorted populations of defined phenotype, we show that the genetic fingerprint of these CD4(+)CD3(-) cells is distinct from dendritic cells, plasmacytoid dendritic cells, T cells, B cells, and NK cells. In contrast, it is highly similar to CD4(+)CD3(-) cells isolated from embryonic and neonatal tissues, with the exception that only adult populations express OX40L and CD30L. We have previously reported that IL-7 signals regulate CD30L expression. In the present study, we show that both neonatal and adult CD4(+)CD3(-) cells express the TNF family member, death receptor 3 (TNFRSF25), and that addition of TL1A (TNFSF15), the ligand for death receptor 3, up-regulates OX40L on neonatal CD4(+)CD3(-) cells. Finally, we demonstrate that this differentiation occurs in vivo: neonatal CD4(+)CD3(-) cells up-regulate both CD30L and OX40L after adoptive transfer into an adult recipient.

AB - We report here the quantitative expression of a set of immunity-related genes, including TNF family members, chemokine receptors, and transcription factors, in a CD4(+)CD3(-) accessory cell. By correlating gene expression between cell-sorted populations of defined phenotype, we show that the genetic fingerprint of these CD4(+)CD3(-) cells is distinct from dendritic cells, plasmacytoid dendritic cells, T cells, B cells, and NK cells. In contrast, it is highly similar to CD4(+)CD3(-) cells isolated from embryonic and neonatal tissues, with the exception that only adult populations express OX40L and CD30L. We have previously reported that IL-7 signals regulate CD30L expression. In the present study, we show that both neonatal and adult CD4(+)CD3(-) cells express the TNF family member, death receptor 3 (TNFRSF25), and that addition of TL1A (TNFSF15), the ligand for death receptor 3, up-regulates OX40L on neonatal CD4(+)CD3(-) cells. Finally, we demonstrate that this differentiation occurs in vivo: neonatal CD4(+)CD3(-) cells up-regulate both CD30L and OX40L after adoptive transfer into an adult recipient.

M3 - Article

C2 - 16920944

VL - 177

SP - 3074

EP - 3081

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

ER -