Nelson’s syndrome: an update
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
Nelson's syndrome (NS) is a condition which may develop in patients with Cushing's disease after bilateral adrenalectomy. Although there is no formal consensus on what defines NS, corticotroph tumor growth and/or gradually increasing ACTH levels are important diagnostic elements. Pathogenesis is unclear and well-established predictive factors are lacking; high ACTH during the first year after bilateral adrenalectomy is the most consistently reported predictive parameter. Management is individualized and includes surgery, with or without radiotherapy, radiotherapy alone, and observation; medical treatments have shown inconsistent results. A subset of tumors demonstrates aggressive behavior with challenging management, malignant transformation and poor prognosis.
|Number of pages||20|
|Journal||Endocrinology and Metabolism Clinics of North America|
|Early online date||30 Jul 2020|
|Publication status||Published - Sep 2020|