TY - JOUR
T1 - Nasopharyngeal carcinoma and the EBV-specific T cell response: Prospects for immunotherapy
AU - Lee, Steven
PY - 2002/12/1
Y1 - 2002/12/1
N2 - T cells specific for Epstein-Barr virus (EBV) can effectively target the virus-transformed B lymphoproliferative lesions that arise in immunosuppressed transplant patients. This review explores the possibility of developing similar T cell-based strategies to treat an EBV-positive epithelial tumour, nasopharyngeal carcinoma (NPC), which arises in relatively immunocompetent individuals and where EBV antigen expression in the tumour is more limited.
AB - T cells specific for Epstein-Barr virus (EBV) can effectively target the virus-transformed B lymphoproliferative lesions that arise in immunosuppressed transplant patients. This review explores the possibility of developing similar T cell-based strategies to treat an EBV-positive epithelial tumour, nasopharyngeal carcinoma (NPC), which arises in relatively immunocompetent individuals and where EBV antigen expression in the tumour is more limited.
UR - http://www.scopus.com/inward/record.url?scp=0036435174&partnerID=8YFLogxK
U2 - 10.1016/S1044-579X(02)00089-5
DO - 10.1016/S1044-579X(02)00089-5
M3 - Article
C2 - 12450732
VL - 12
SP - 463
EP - 471
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
IS - 6
ER -