Nasopharyngeal carcinoma and the EBV-specific T cell response: Prospects for immunotherapy

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Colleges, School and Institutes


T cells specific for Epstein-Barr virus (EBV) can effectively target the virus-transformed B lymphoproliferative lesions that arise in immunosuppressed transplant patients. This review explores the possibility of developing similar T cell-based strategies to treat an EBV-positive epithelial tumour, nasopharyngeal carcinoma (NPC), which arises in relatively immunocompetent individuals and where EBV antigen expression in the tumour is more limited.


Original languageEnglish
Pages (from-to)463-471
Number of pages9
JournalSeminars in Cancer Biology
Issue number6
Publication statusPublished - 1 Dec 2002