Mutations in gyrA gene of quinolone-resistant Salmonella serotypes isolated from humans and animals

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Colleges, School and Institutes

Abstract

The quinolone resistance-determining regions (QRDRs) of the gyrA genes of quinolone-resistant clinical and veterinary salmonella isolates were sequenced. Substitutions analogous to a substitution of a Ser to a Phe at position 83 (Ser83-->Phe) and Asp87-->Gly or Tyr in Escherichia coli were found, as was a single novel mutation outside of the QRDR resulting in Ala119-->Glu. The data suggest that gyrA mutations are associated with quinolone resistance in veterinary and clinical salmonella isolates and that the limits of the QRDR may require revision.

Details

Original languageEnglish
Pages (from-to)1009-13
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume40
Issue number4
Publication statusPublished - Apr 1996

Keywords

  • Amino Acid Sequence, Animals, Anti-Infective Agents, Base Sequence, DNA Gyrase, DNA Topoisomerases, Type II, Drug Resistance, Microbial, Escherichia coli, Fluoroquinolones, Humans, Molecular Sequence Data, Mutation, Salmonella, Sequence Homology