Mutations in gyrA gene of quinolone-resistant Salmonella serotypes isolated from humans and animals
Research output: Contribution to journal › Article › peer-review
The quinolone resistance-determining regions (QRDRs) of the gyrA genes of quinolone-resistant clinical and veterinary salmonella isolates were sequenced. Substitutions analogous to a substitution of a Ser to a Phe at position 83 (Ser83-->Phe) and Asp87-->Gly or Tyr in Escherichia coli were found, as was a single novel mutation outside of the QRDR resulting in Ala119-->Glu. The data suggest that gyrA mutations are associated with quinolone resistance in veterinary and clinical salmonella isolates and that the limits of the QRDR may require revision.
|Number of pages||5|
|Journal||Antimicrobial Agents and Chemotherapy|
|Publication status||Published - Apr 1996|
- Amino Acid Sequence, Animals, Anti-Infective Agents, Base Sequence, DNA Gyrase, DNA Topoisomerases, Type II, Drug Resistance, Microbial, Escherichia coli, Fluoroquinolones, Humans, Molecular Sequence Data, Mutation, Salmonella, Sequence Homology