Muscarinic receptor subtypes and the selectivity of agonists and antagonists
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
Receptors may be grouped into superfamilies, according to their mechanism. Muscarinic receptors belong to one such superfamily, that of the G-protein coupled receptors. Subtypes of muscarinic receptors may be defined according to their primary amino acid sequence, their mechanism and their pharmacology. However, there is as yet no consistent scheme to explain the pharmacology and function of each molecular subtype. The pharmacological tools which distinguish between muscarinic receptor subtypes are described and the emerging evidence for the location of the ligand binding site is discussed.
|Number of pages||10|
|Volume||37 Suppl 1|
|Publication status||Published - 1988|
- (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride, Amino Acid Sequence, Animals, Binding Sites, Molecular Sequence Data, Molecular Structure, Pirenzepine, Receptors, Muscarinic