Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster

Research output: Contribution to journalArticle

Authors

  • Sian Cooper
  • RJ Cox
  • J Crosby
  • MP Crump
  • W Laosripaiboon
  • TJ Simpson

Colleges, School and Institutes

Abstract

Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.

Details

Original languageEnglish
Pages (from-to)1179-1181
Number of pages3
JournalChemical Communications
Issue number9
Publication statusPublished - 1 Jan 2005