Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens

Research output: Contribution to journalArticle


  • J Wu
  • SM Cooper
  • RJ Cox
  • J Crosby
  • MP Crump
  • TJ Simpson
  • CL Willis

Colleges, School and Institutes


Mutation of the HMG-CoA synthase encoding mupH gene in Pseudomonas fluorescens gives rise to a new metabolite formed from a truncated polyketide intermediate, providing in vivo evidence for the roles of mupH and cognate genes found in several "AT-less" and other bacterial PKS gene clusters responsible for the biosynthesis of diverse metabolites containing acetate/propionate derived side chains.


Original languageEnglish
Pages (from-to)2040-2042
Number of pages3
JournalChemical Communications
Publication statusPublished - 1 Jan 2007