Mupirocin F: structure elucidation, synthesis and rearrangements
Research output: Contribution to journal › Article
Colleges, School and Institutes
The structures of two novel metabolites, mupirocins F and F2, from extracts of the mupF mutant of Pseudomonas fluorescens were elucidated by spectroscopic methods. Methyl mupirocin F was synthesised from the triol methyl pseudomonate A by selective oxidation of the 7-hydroxyl group thus firmly establishing the structure of the natural product. Rearrangement of the densely functionalised skeleton led to unusual bicyclic and tricyclic products. (C) 2011 Elsevier Ltd. All rights reserved.
|Number of pages||9|
|Publication status||Published - 1 Jul 2011|
- Rearrangements, Structure elucidation, Selective oxidation, Polyketide