Multiple-scale neuroendocrine signals connect brain and pituitary hormone rhythms

Research output: Contribution to journalArticle

Authors

  • Nicola Romanò
  • Anne Guillou
  • David Hodson
  • Agnes O Martin
  • Patrice Mollard

Colleges, School and Institutes

External organisations

  • Univ Montpellier 1

Abstract

Small assemblies of hypothalamic “parvocellular” neurons release their neuroendocrine signals at the median eminence (ME) to control long-lasting pituitary hormone rhythms essential for homeostasis. How such rapid hypothalamic neurotransmission leads to slowly evolving hormonal signals remains unknown. Here, we show that the temporal organization of dopamine (DA) release events in freely behaving animals relies on a set of characteristic features that are adapted to the dynamic dopaminergic control of pituitary prolactin secretion, a key reproductive hormone. First, locally generated DA release signals are organized over more than four orders of magnitude (0.001 Hz–10 Hz). Second, these DA events are finely tuned within and between frequency domains as building blocks that recur over days to weeks. Third, an integration time window is detected across the ME and consists of high-frequency DA discharges that are coordinated within the minutes range. Thus, a hierarchical combination of time-scaled neuroendocrine signals displays local–global integration to connect brain–pituitary rhythms and pace hormone secretion.

Bibliographic note

Freely available online through the PNAS open access option

Details

Original languageEnglish
Pages (from-to)2379–2382
JournalNational Academy of Sciences. Proceedings
Volume114
Issue number9
Early online date13 Feb 2017
Publication statusPublished - 28 Feb 2017