Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence

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Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence. / Varecza, Z; Kvell, K; Talaber, G; Miskei, G; Csongei, V; Bartis, D; Anderson, Graham; Jenkinson, Eric; Pongracz, JE.

In: Mechanisms of Ageing and Development, Vol. 132, No. 5, 01.05.2011, p. 249-256.

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Varecza, Z ; Kvell, K ; Talaber, G ; Miskei, G ; Csongei, V ; Bartis, D ; Anderson, Graham ; Jenkinson, Eric ; Pongracz, JE. / Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence. In: Mechanisms of Ageing and Development. 2011 ; Vol. 132, No. 5. pp. 249-256.

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@article{c5bb5ff5021248ce80e4fc442d81af62,
title = "Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence",
abstract = "Members of the Wnt family of secreted glyco-lipo-proteins affect intrathymic T-cell development and are abundantly secreted by thymic epithelial cells (TECs) that create the specific microenvironment for thymocytes to develop into mature T-cells. During ageing, Wnt expression declines allowing adipoid involution of the thymic epithelium leading to reduced naive T-cell output. The protein kinase C (PKC) family of serine-threonine kinases is involved in numerous intracellular biochemical processes, including Wnt signal transduction. In the present study. PKC delta expression is shown to increase with age and to co-localise with Wnt receptors Frizzled (Fz)-4 and -6. It is also demonstrated that connective tissue growth factor (CTGF) is a Wnt-4 target gene and is potentially involved in a negative feed-back loop of Wnt signal regulation. Down-regulation of Wnt-4 expression and activation of multiple repressor pathways suppressing beta-catenin dependent signalling in TECs contribute to the initiation of thymic senescence. (C) 2011 Elsevier Ireland Ltd. All rights reserved.",
keywords = "PKC delta, Thymic epithelium, Wnt signalling, Thymic atrophy",
author = "Z Varecza and K Kvell and G Talaber and G Miskei and V Csongei and D Bartis and Graham Anderson and Eric Jenkinson and JE Pongracz",
year = "2011",
month = may,
day = "1",
doi = "10.1016/j.mad.2011.04.007",
language = "English",
volume = "132",
pages = "249--256",
journal = "Mechanisms of Ageing and Development",
issn = "0047-6374",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence

AU - Varecza, Z

AU - Kvell, K

AU - Talaber, G

AU - Miskei, G

AU - Csongei, V

AU - Bartis, D

AU - Anderson, Graham

AU - Jenkinson, Eric

AU - Pongracz, JE

PY - 2011/5/1

Y1 - 2011/5/1

N2 - Members of the Wnt family of secreted glyco-lipo-proteins affect intrathymic T-cell development and are abundantly secreted by thymic epithelial cells (TECs) that create the specific microenvironment for thymocytes to develop into mature T-cells. During ageing, Wnt expression declines allowing adipoid involution of the thymic epithelium leading to reduced naive T-cell output. The protein kinase C (PKC) family of serine-threonine kinases is involved in numerous intracellular biochemical processes, including Wnt signal transduction. In the present study. PKC delta expression is shown to increase with age and to co-localise with Wnt receptors Frizzled (Fz)-4 and -6. It is also demonstrated that connective tissue growth factor (CTGF) is a Wnt-4 target gene and is potentially involved in a negative feed-back loop of Wnt signal regulation. Down-regulation of Wnt-4 expression and activation of multiple repressor pathways suppressing beta-catenin dependent signalling in TECs contribute to the initiation of thymic senescence. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

AB - Members of the Wnt family of secreted glyco-lipo-proteins affect intrathymic T-cell development and are abundantly secreted by thymic epithelial cells (TECs) that create the specific microenvironment for thymocytes to develop into mature T-cells. During ageing, Wnt expression declines allowing adipoid involution of the thymic epithelium leading to reduced naive T-cell output. The protein kinase C (PKC) family of serine-threonine kinases is involved in numerous intracellular biochemical processes, including Wnt signal transduction. In the present study. PKC delta expression is shown to increase with age and to co-localise with Wnt receptors Frizzled (Fz)-4 and -6. It is also demonstrated that connective tissue growth factor (CTGF) is a Wnt-4 target gene and is potentially involved in a negative feed-back loop of Wnt signal regulation. Down-regulation of Wnt-4 expression and activation of multiple repressor pathways suppressing beta-catenin dependent signalling in TECs contribute to the initiation of thymic senescence. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

KW - PKC delta

KW - Thymic epithelium

KW - Wnt signalling

KW - Thymic atrophy

U2 - 10.1016/j.mad.2011.04.007

DO - 10.1016/j.mad.2011.04.007

M3 - Article

C2 - 21549744

VL - 132

SP - 249

EP - 256

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

SN - 0047-6374

IS - 5

ER -