Multi-Method Assessment of Sleep in Children With Angelman Syndrome: A Case-Controlled Study

Research output: Contribution to journalArticlepeer-review

Authors

  • Jayne Trickett
  • Hayley Denyer
  • Emma Clarkson
  • Paul Gringras

Colleges, School and Institutes

External organisations

  • Leicester Diabetes Centre University Hospitals Leicester Leicester
  • Forward Thinking Birmingham
  • THE HUNTERCOMBE GROUP

Abstract

Objectives: To assess sleep quality and timing in children with Angelman syndrome (AS) with sleep problems using questionnaires and actigraphy and contrast sleep parameters to those of typically developing (TD) children matched for age and sex. Methods: Week-long actigraphy assessments were undertaken with children with AS (n = 20) with parent-reported sleep difficulties and compared with age and sex matched TD controls. The presence of severe sleep problems was assessed using the modified Simonds and Parraga sleep questionnaire. Sleep hygiene was measured using the Family Inventory of Sleep Habits. Results: Actigraphy and parent-completed sleep diary data indicated that children with AS had significantly earlier bedtimes (p = .003, Cohen d = .47) and poorer sleep efficiency (78%, p = .04, d = .33) than TD children (84%). No significant differences in total sleep time, sleep onset latency or wake after sleep onset were found between the two groups. The expected relationship between later bedtimes and increasing age found for the TD group (p < .001, β.78) was not evidenced for the AS group (p = .09, β.39). Considerable inter-individual and night to night variation in actigraphy assessed total sleep time and wake after sleep onset was found for children with AS compared to TD children. Parent report indicated that a greater proportion of children with AS had severe night waking problems compared to TD children (81 versus 5%). No significant differences in sleep hygiene and excessive daytime sleepiness were found between the two groups (p > .05). Conclusions: This study reports the largest objective dataset of sleep quality parameters in children with AS. Sleep quality in this group was characterised by poor efficiency and significant intra- and inter-individual variability that warrants further investigation. This variability should inform assessment and intervention for sleep in children with AS, as averages of total sleep, even across a 7 day period may not capture the difficulties with night waking highlighted by parental questionnaire report.

Bibliographic note

Copyright © 2019 Trickett, Oliver, Heald, Denyer, Surtees, Clarkson, Gringras and Richards.

Details

Original languageEnglish
Article number874
JournalFrontiers in Psychiatry
Volume10
Publication statusPublished - 29 Nov 2019

Keywords

  • Angelman syndrome, actigraphy, case–control, intellectual disability, sleep