Multifunctional Bacterial Multi-Drug Efflux Pumps – not just for resistance

Research output: Contribution to journalReview article

Authors

Colleges, School and Institutes

Abstract

It is well established that multidrug-resistance efflux pumps encoded by bacteria can confer clinically relevant resistance to antibiotics. It is now understood that these efflux pumps also have a physiological role(s). They can confer resistance to natural substances produced by the host, including bile, hormones and host-defence molecules. In addition, some efflux pumps of the resistance nodulation division (RND) family have been shown to have a role in the colonization and the persistence of bacteria in the host. Here, I present the accumulating evidence that multidrug-resistance efflux pumps have roles in bacterial pathogenicity and propose that these pumps therefore have greater clinical relevance than is usually attributed to them.

Details

Original languageEnglish
Pages (from-to)629-636
Number of pages8
JournalNature Reviews Microbiology
Volume4
Issue number8
Publication statusPublished - 1 Jan 2006