Multifocality in Sporadic Medullary Thyroid Carcinoma: An International Multicenter Study
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- 1 Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center , Columbus, Ohio.
- 2 Center for Biostatistics, The Ohio State University Wexner Medical Center , Columbus, Ohio.
- 3 Section of Endocrine Surgery, University of Wisconsin School of Medicine and Public Health , Madison, Wisconsin.
- 4 Department of Clinical Medicine and Surgery, University of Naples Federico II , Naples, Italy .
- 5 Division of Endocrinology, Laboratory of Molecular and Translational Endocrinology, Department of Medicine, Federal University of Sao Paulo , São Paulo, Brazil .
- 6 Section of Endocrinology and Metabolism, Department of Medical, Surgical, and Neurological Sciences, University of Siena , Siena, Italy .
- 7 Department of Endocrinology and Diabetes, Alfred Health, Monash University , Melbourne, Australia .
- 8 Département of Endocrinology and Nephrology, Pierre Oudot Hospital , Bourgoin-Jallieu, France .
- 10 Department of Internal Medicine, Radboud University Medical Centre , Nijmegen, The Netherlands .
- 11 Department of Internal Medicine, Albert Schweitzer Hospital , Dordrecht, The Netherlands .
- 12 Evgenidion Hospital, Unit of Endocrinology, Diabetes and Metabolism, Thyroid Section, University of Athens , Athens, Greece .
- 14 Department of Medicine, Institut Jules Bordet , Brussels, Belgium .
- 15 Dipartimento Di Medicina Interna, University of Roma La Sapienza , Rome, Italy .
- 16 Veracyte, Inc. , South San Francisco, California.
BACKGROUND: Current surgical standard of care in sporadic medullary thyroid carcinoma (sMTC) consists of a minimum of total thyroidectomy with central neck dissection. Some have suggested thyroid lobectomy with isthmusectomy and central neck dissection for patients with sMTC, given their lower frequency of bilateral disease, although this topic has not been thoroughly studied. This study assessed the prevalence of multifocality in sMTC via a large international multi-institutional retrospective review to quantify this prevalence, including the impact of geography, to assess more accurately the risks associated with alternative surgical approaches.
METHODS: A retrospective chart review of sMTC patients from 11 institutions over 29 years (1983-2011) was undertaken. Data regarding focality, extent of disease, RET germline analysis plus family and clinical history for multiple endocrine neoplasia type 2 (MEN2), and demographic data were collected and analyzed.
RESULTS: Patients from four continents and seven countries were included in the sample. Data for 313 patients with documented sMTC were collected. Of these, 81.2% were confirmed with negative RET germline testing, while the remaining 18.8% demonstrated a negative family history and no manifestations of MEN2 syndromes other than MTC. Bilateral disease was identified in 17/306 (5.6%) patients, while multifocal disease was noted in 50/312 (16.0%) sMTC patients. When only accounting for germline negative patients, these rates were not significantly different (5.6% and 17%, respectively). Among them, when disease was unifocal in the ipsilateral lobe and isthmus, bilateral disease was present in 6/212 (2.8%) cases. When disease was multifocal in the ipsilateral lobe or isthmus, then bilateral disease was present in 8/37 (21.6%) cases (p < 0.001). No geographic differences in focality were identified.
CONCLUSIONS: The 5.6% prevalence of bilateral foci in sMTC suggests that total thyroidectomy should remain the standard of care for initial surgery, as less complete thyroid surgery may fail to address fully the primary site of disease. Whether ipsilateral tumor focality should be an independent factor determining the need for completion thyroidectomy when sMTC is diagnosed after hemithyroidectomy remains to be determined.
|Number of pages||10|
|Early online date||11 Oct 2016|
|Publication status||Published - Nov 2016|
- Journal Article