Multidrug efflux pumps: structure, function and regulation

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Multidrug efflux pumps : structure, function and regulation. / Du, Dijun; Wang-Kan, Xuan; Neuberger, Arthur; van Veen, Hendrik W.; Pos, Klaas M.; Piddock, Laura J.V.; Luisi, Ben F.

In: Nature Reviews Microbiology, Vol. 16, No. 9, 12.07.2018, p. 523-539.

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Du, Dijun ; Wang-Kan, Xuan ; Neuberger, Arthur ; van Veen, Hendrik W. ; Pos, Klaas M. ; Piddock, Laura J.V. ; Luisi, Ben F. / Multidrug efflux pumps : structure, function and regulation. In: Nature Reviews Microbiology. 2018 ; Vol. 16, No. 9. pp. 523-539.

Bibtex

@article{4be9d5e2334d4223ab49b9245c486172,
title = "Multidrug efflux pumps: structure, function and regulation",
abstract = "Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor is the capacity of bacteria to rapidly export drugs through the intrinsic activity of efflux pumps. In this Review, we describe recent advances that have increased our understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria. Clinical and laboratory data indicate that efflux pumps function not only in the drug extrusion process but also in virulence and the adaptive responses that contribute to antimicrobial resistance during infection. The emerging picture of the structure, function and regulation of efflux pumps suggests opportunities for countering their activities.",
author = "Dijun Du and Xuan Wang-Kan and Arthur Neuberger and {van Veen}, {Hendrik W.} and Pos, {Klaas M.} and Piddock, {Laura J.V.} and Luisi, {Ben F.}",
year = "2018",
month = "7",
day = "12",
doi = "10.1038/s41579-018-0048-6",
language = "English",
volume = "16",
pages = "523--539",
journal = "Nature Reviews Microbiology",
issn = "1740-1526",
publisher = "Nature Publishing Group",
number = "9",

}

RIS

TY - JOUR

T1 - Multidrug efflux pumps

T2 - structure, function and regulation

AU - Du, Dijun

AU - Wang-Kan, Xuan

AU - Neuberger, Arthur

AU - van Veen, Hendrik W.

AU - Pos, Klaas M.

AU - Piddock, Laura J.V.

AU - Luisi, Ben F.

PY - 2018/7/12

Y1 - 2018/7/12

N2 - Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor is the capacity of bacteria to rapidly export drugs through the intrinsic activity of efflux pumps. In this Review, we describe recent advances that have increased our understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria. Clinical and laboratory data indicate that efflux pumps function not only in the drug extrusion process but also in virulence and the adaptive responses that contribute to antimicrobial resistance during infection. The emerging picture of the structure, function and regulation of efflux pumps suggests opportunities for countering their activities.

AB - Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor is the capacity of bacteria to rapidly export drugs through the intrinsic activity of efflux pumps. In this Review, we describe recent advances that have increased our understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria. Clinical and laboratory data indicate that efflux pumps function not only in the drug extrusion process but also in virulence and the adaptive responses that contribute to antimicrobial resistance during infection. The emerging picture of the structure, function and regulation of efflux pumps suggests opportunities for countering their activities.

UR - http://www.scopus.com/inward/record.url?scp=85049771675&partnerID=8YFLogxK

U2 - 10.1038/s41579-018-0048-6

DO - 10.1038/s41579-018-0048-6

M3 - Review article

AN - SCOPUS:85049771675

VL - 16

SP - 523

EP - 539

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

SN - 1740-1526

IS - 9

ER -