Mortality study of 18 000 patients treated with omeprazole

Research output: Contribution to journalArticle


  • DN Bateman
  • D Colin-Jones
  • S Hartz
  • RF Logan
  • MS Murphy
  • KR Paterson
  • R Rowsell
  • SG Thomas
  • M Vessey

Colleges, School and Institutes


Background: The long term safety of potent gastric acid suppressive therapy has yet to be established. Method: General practice record review at a median interval of 26 months followed by retrieval of details of all deaths within four years using the UK National Health Service Central Registers in 17 936 patients prescribed omeprazole in 1993–1995. Death rates were compared with general population rates. Results: Records of 17 489 patients (97.5%) were examined. A total of 12 703 patients received further scripts for antisecretory drugs, 8097 for omeprazole only (65.6%): 3097 patients have died. All cause mortality was higher in the first year (observed/expected (O/E) 1.44 (95% confidence intervals (CI) 1.34–1.55); p


Original languageEnglish
Pages (from-to)942-946
Number of pages5
Issue number7
Publication statusPublished - 1 Jul 2003