Mortality in Patients with Pituitary Disease

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@article{fc3a0404614d41fc8c49d518775edab0,
title = "Mortality in Patients with Pituitary Disease",
abstract = "Pituitary disease is associated with increased mortality predominantly due to vascular disease. Control of cortisol secretion and GH hypersecretion (and cardiovascular risk factor reduction) is key in the reduction of mortality in patients with Cushing's disease and acromegaly, retrospectively. For patients with acromegaly, the role of IGF-I is less clear-cut. Confounding pituitary hormone deficiencies such as gonadotropins and particularly ACTH deficiency (with higher doses of hydrocortisone replacement) may have a detrimental effect on outcome in patients with pituitary disease. Pituitary radiotherapy is a further factor that has been associated with increased mortality (particularly cerebrovascular). Although standardized mortality ratios in pituitary disease are falling due to improved treatment, mortality for many conditions are still elevated above that of the general population, and therefore further measures are needed. Craniopharyngioma patients have a particularly increased risk of mortality as a result of the tumor itself and treatment to control tumor growth; this is a key area for future research in order to optimize the outcome for these patients. (Endocrine Reviews 31: 301-342, 2010)",
author = "Mark Sherlock and John Ayuk and Jeremy Tomlinson and Andrew Toogood and {Aragon Alonso}, Aurora and Michael Sheppard and Andrew Bates and Paul Stewart",
year = "2010",
month = jun
day = "1",
doi = "10.1210/er.2009-0033",
language = "English",
volume = "31",
pages = "301--342",
journal = "Endocrine Reviews",
issn = "0163-769X",
publisher = "The Endocrine Society",
number = "3",

}

RIS

TY - JOUR

T1 - Mortality in Patients with Pituitary Disease

AU - Sherlock, Mark

AU - Ayuk, John

AU - Tomlinson, Jeremy

AU - Toogood, Andrew

AU - Aragon Alonso, Aurora

AU - Sheppard, Michael

AU - Bates, Andrew

AU - Stewart, Paul

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Pituitary disease is associated with increased mortality predominantly due to vascular disease. Control of cortisol secretion and GH hypersecretion (and cardiovascular risk factor reduction) is key in the reduction of mortality in patients with Cushing's disease and acromegaly, retrospectively. For patients with acromegaly, the role of IGF-I is less clear-cut. Confounding pituitary hormone deficiencies such as gonadotropins and particularly ACTH deficiency (with higher doses of hydrocortisone replacement) may have a detrimental effect on outcome in patients with pituitary disease. Pituitary radiotherapy is a further factor that has been associated with increased mortality (particularly cerebrovascular). Although standardized mortality ratios in pituitary disease are falling due to improved treatment, mortality for many conditions are still elevated above that of the general population, and therefore further measures are needed. Craniopharyngioma patients have a particularly increased risk of mortality as a result of the tumor itself and treatment to control tumor growth; this is a key area for future research in order to optimize the outcome for these patients. (Endocrine Reviews 31: 301-342, 2010)

AB - Pituitary disease is associated with increased mortality predominantly due to vascular disease. Control of cortisol secretion and GH hypersecretion (and cardiovascular risk factor reduction) is key in the reduction of mortality in patients with Cushing's disease and acromegaly, retrospectively. For patients with acromegaly, the role of IGF-I is less clear-cut. Confounding pituitary hormone deficiencies such as gonadotropins and particularly ACTH deficiency (with higher doses of hydrocortisone replacement) may have a detrimental effect on outcome in patients with pituitary disease. Pituitary radiotherapy is a further factor that has been associated with increased mortality (particularly cerebrovascular). Although standardized mortality ratios in pituitary disease are falling due to improved treatment, mortality for many conditions are still elevated above that of the general population, and therefore further measures are needed. Craniopharyngioma patients have a particularly increased risk of mortality as a result of the tumor itself and treatment to control tumor growth; this is a key area for future research in order to optimize the outcome for these patients. (Endocrine Reviews 31: 301-342, 2010)

U2 - 10.1210/er.2009-0033

DO - 10.1210/er.2009-0033

M3 - Review article

C2 - 20086217

VL - 31

SP - 301

EP - 342

JO - Endocrine Reviews

JF - Endocrine Reviews

SN - 0163-769X

IS - 3

ER -