Monitoring disease activity using growth hormone and insulin like growth factor-I in the follow up of 501 patients with acromegaly.

Research output: Contribution to journalArticle


SUMMARY Context: The aims of treatment in patients with acromegaly are to achieve serum GH/ IGF-I concentrations associated with cure or normalisation of mortality and alleviation of symptoms. Objective and methods: Using the West Midlands Acromegaly database (n=501) we investigated the reliability of basal fasting GH in predicting nadir or mean GH during oral glucose tolerance test (OGTT) or growth hormone day curve (GHDC), respectively, the degree of discordance between disease activity measured by GH and IGF-I values and the effect of radiotherapy on the above relationships. In total 773 OGTT and 507 GHDC were performed. Results: Basal fasting GH was strongly correlated with nadir/ mean GH on OGTT/GHDC (r=+0.87, p


Original languageEnglish
JournalClinical Endocrinology
Publication statusPublished - 27 Oct 2008